Reactome | G-protein beta 1 subunit [cytosol]

G-protein beta 1 subunit [cytosol]

Stable Identifier

R-MMU-4551475

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Gnb1, GBB1_MOUSE, Gnb1

Locations in the PathwayBrowser

Expand all

Hemostasis (Mus musculus)

- Platelet activation, signaling and aggregation (Mus musculus)
  - Signal amplification (Mus musculus)
    - ADP signalling through P2Y purinoceptor 1 (Mus musculus)
      - Dissociation of the P2Y purinoceptor 1:Gq complex (Mus musculus)
        
        ADP:P2RY1:G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        G protein-GTP [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
    - ADP signalling through P2Y purinoceptor 12 (Mus musculus)
      - Activated P2Y purinoceptor 12 binds G-protein Gi (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
      - Dissociation of the P2Y purinoceptor 12:Gi complex (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
      - Gi activation by P2Y purinoceptor 12 (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
    - Thromboxane signalling through TP receptor (Mus musculus)
      - Activated TP receptor binds G-protein G13 (Mus musculus)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
      - Activated TP receptor binds G-proten Gq (Mus musculus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
      - Dissociation of the TP:G13 complex (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
      - Dissociation of the TP:Gq complex (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        G protein-GTP [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
      - G13 activation by TP receptor (Mus musculus)
        
        TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
      - Gq activation by TP receptor (Mus musculus)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Mus musculus)
        
        G protein-GTP [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
  - Thrombin signalling through proteinase activated receptors (PARs) (Mus musculus)
    - Thrombin-activated PARs activate G12/13 (Mus musculus)
      - Thrombin activated PAR:G12/13 (active) [plasma membrane] (Mus musculus)
        
        G-protein G12/G13 (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein G12 (active) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
      - Thrombin activated PAR:G12/13 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein G12/G13 (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein G12 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
    - Thrombin-activated PARs activate Gq (Mus musculus)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Mus musculus)
        
        G protein-GTP [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
    - Thrombin-activated PARs binds G-protein Gq (Mus musculus)
      - Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
      - Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
    - Thrombin-activated PARs:G12/13 (active) dissociate (Mus musculus)
      - G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
      - Thrombin activated PAR:G12/13 (active) [plasma membrane] (Mus musculus)
        
        G-protein G12/G13 (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein G12 (active) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
    - Thrombin-activated PARs:Gq (active) dissociate (Mus musculus)
      - G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
      - Thrombin-activated PAR:Gq (active) [plasma membrane] (Mus musculus)
        
        G protein-GTP [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
- Platelet homeostasis (Mus musculus)
  - Prostacyclin signalling through prostacyclin receptor (Mus musculus)
    - Gs activation by prostacyclin receptor (Mus musculus)
      - Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gs (active) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
      - Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Mus musculus)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)

Neuronal System (Mus musculus)

- Potassium Channels (Mus musculus)
  - Inwardly rectifying K+ channels (Mus musculus)
    - G protein gated Potassium channels (Mus musculus)
      - Activation of G protein gated Potassium channels (Mus musculus)
        
        Activation of GIRK/Kir3 Channels (Mus musculus)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        Association of GABA B receptor with G protein beta-gamma subunits (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Mus musculus)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
- Transmission across Chemical Synapses (Mus musculus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Mus musculus)
    - Activation of kainate receptors upon glutamate binding (Mus musculus)
      - Presynaptic function of Kainate receptors (Mus musculus)
        
        Activation of GRIK3 homomer (Mus musculus)
        
        G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        Kainate receptor-glutamate-Gprotein complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma:PLC beta 1/2/3 [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
    - GABA receptor activation (Mus musculus)
      - GABA B receptor activation (Mus musculus)
        
        Activation of GABAB receptors (Mus musculus)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Mus musculus)
        
        Activation of GIRK/Kir3 Channels (Mus musculus)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        Association of GABA B receptor with G protein beta-gamma subunits (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Mus musculus)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta-gamma complex [plasma membrane] (Mus musculus)
        
        G-protein beta subunit [cytosol] (Mus musculus)
        
        G-protein beta 1 subunit [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P62874 Gnb1

Gene Names

Gnb1

Chain

initiator methionine:1, chain:2-340

Reference Genes

BioGPS Gene:14688 Gnb1

KEGG:mmu:14688 Gnb1

Monarch:14688 Gnb1

NCBI Gene:14688 Gnb1

UCSC:P62874 Gnb1

Reference Transcript

Other Identifiers

10511069

1417432_a_at

1425908_at

1454696_at

14688

17422573

4363080

4434023

4435329

4461064

4472576

4473803

4491253

4577263

4726610

4768140

4792311

4836757

4838838

4904723

4943350

4955036

4958792

5016336

5056093

5207393

5239833

5310283

5394579

5398743

5555690

94853_at

94854_g_at

97458_at

A_51_P335081

A_52_P205991

A_52_P304858

A_52_P470505

GE1465206

GE34498

GO:0001750

GO:0003924

GO:0005515

GO:0005737

GO:0005834

GO:0005886

GO:0007165

GO:0007186

GO:0007200

GO:0007603

GO:0008092

GO:0008283

GO:0010659

GO:0016787

GO:0030159

GO:0030507

GO:0043209

GO:0044877

GO:0045202

GO:0047391

GO:0048856

GO:0050877

GO:0050909

GO:0051020

GO:0060041

GO:0060090

GO:0071456

ILMN_2733852

Msa.3240.0_f_at

U29055_f_at

mMC009419

Participates

as a member of

as a candidate of

G-protein beta subunit [cytosol] (Mus musculus)

Other forms of this molecule

G-protein beta 1 subunit [plasma membrane]

Gnb1 [photoreceptor disc membrane]

Inferred From

Unfolded GNB1 [cytosol] (Homo sapiens)

Partially folded GNB1 [cytosol] (Homo sapiens)

GNB1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_032168.1, NP_001407898.1, XP_017175466.1, NP_001407900.1, NP_001153489.1, NP_001153488.1, NP_001407899.1, NP_001407897.1, NP_001407896.1

ENSEMBL

ENSMUSP00000135091, ENSMUST00000165335, ENSMUSG00000029064, ENSMUST00000105616, ENSMUSP00000130123, ENSMUSP00000030940, ENSMUSP00000101241, ENSMUST00000176637, ENSMUST00000030940

PRO

P62874

MGI

95781

GlyGen

P62874

PDB

8IHF, 6K41, 6RMV, 6K42, 8IHB, 7Y15, 8IHJ, 8IHI, 8IHH, 7Y12

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q62108 Dlg4	3	SAP-90 [plasma membrane] (R-MMU-443606) Dlg4 [endocytic vesicle membrane] (R-MMU-416847) Dlg4 [cytosol] (R-MMU-6794267)	0.527	3

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