Dscam binds Dcc

Stable Identifier
R-MMU-451360
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dscam binds Dcc
DSCAM and DCC (Deleted in Colorectal Carcinoma) form a receptor complex in commissural axons in the absence of netrin1. They associate through a transmembrane interaction. The functional implication of this interaction is not known, but may allow DCC and DSCAM to contribute to other guidance pathways in a netrin1 independent fashion. It may serve as a way to hold DSCAM and DCC in a resting state, until netrin1 reaches a critical concentration at which both receptors are activated.
Literature References
PubMed ID Title Journal Year
18585357 DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1

Ly, A, Nikolaev, A, Suresh, G, Zheng, Y, Tessier-Lavigne, M, Stein, E

Cell 2008
Participants
Input
Output
Orthologous Events
DSCAM binds DCC (Homo sapiens)
Authored
Garapati, P V  (2010-01-05)
Reviewed
Clemens, JC  (2010-08-10)
Created
Garapati, P V  (2010-01-05)
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