DSCAM binds DCC

Stable Identifier
R-HSA-451345
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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DSCAM binds DCC
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DSCAM and DCC (Deleted in Colorectal Carcinoma) form a receptor complex in commissural axons in the absence of netrin1. They associate through a transmembrane interaction. The functional implication of this interaction is not known, but may allow DCC and DSCAM to contribute to other guidance pathways in a netrin1 independent fashion. It may serve as a way to hold DSCAM and DCC in a resting state, until netrin1 reaches a critical concentration at which both receptors are activated.
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Inferred From
Dscam binds Dcc (Mus musculus)
Authored
Garapati, P V  (2010-01-05)
Reviewed
Clemens, JC  (2010-08-10)
Created
Garapati, P V  (2010-01-05)
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