Reactome | MAP2K7,MAP2K4 [cytosol]

MAP2K7,MAP2K4 [cytosol]

Stable Identifier

R-MMU-450305

Type

Set [DefinedSet]

Species

Mus musculus

Compartment

cytosol

Synonyms

MKK4, MKK7

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-17 signaling (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
    - Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
    - Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
    - Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
    - Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)

Participants

members

Participates

as an input of

Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)

Inferred From

MAP2K7,MAP2K4 [cytosol] (Homo sapiens)