Reactome | MAP2K7 [cytosol]

MAP2K7 [cytosol]

Stable Identifier

R-MMU-450276

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q8CE90

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-17 signaling (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
        
        MAP2K7 [cytosol] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Fc epsilon receptor (FCERI) signaling (Mus musculus)
    - FCERI mediated MAPK activation (Mus musculus)
      - Phosphorylation of MEK7 by MEKK1 (Mus musculus)
        
        MAP2K7 [cytosol] (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
        
        MAP2K7 [cytosol] (Mus musculus)
    - Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
        
        MAP2K7 [cytosol] (Mus musculus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
        
        MAP2K7 [cytosol] (Mus musculus)
    - Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
        
        MAP2K7 [cytosol] (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
        
        MAP2K7 [cytosol] (Mus musculus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
        
        MAP2K7 [cytosol] (Mus musculus)
    - Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
        
        MAP2K7 [cytosol] (Mus musculus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
        
        MAP2K7 [cytosol] (Mus musculus)
    - Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Mus musculus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)
        
        MAP2K7,MAP2K4 [cytosol] (Mus musculus)
        
        MAP2K7 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8CE90

Reference Genes

BioGPS Gene:26400

ENSEMBL:ENSMUSG00000002948

KEGG:mmu:26400

Monarch:26400

NCBI Gene:26400

UCSC:Q8CE90

Reference Transcript

Other Identifiers

10569927

1425393_a_at

1425512_at

1425513_at

1440442_at

1451736_a_at

1457182_at

17498791

17498810

26400

4322870

4335579

4376122

4378427

4434127

4452273

4480589

4490470

4583579

4596049

4596108

4597747

4602018

4638215

4663060

4668175

4743362

4754467

4757729

4773527

4808889

4824991

4864442

4880479

4957080

5006688

5027430

5036469

5077316

5101875

5179809

5223885

5236930

5288783

5298930

5408378

5454039

5466922

5467088

5482826

5511050

5520744

5610306

99036_s_at

A_52_P202350

A_52_P612813

A_52_P70381

A_55_P1974602

A_55_P1976908

A_55_P2482948

A_66_P122675

GE35719

GO:0000165

GO:0000166

GO:0000287

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0004708

GO:0004713

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0006355

GO:0006468

GO:0006915

GO:0006950

GO:0006970

GO:0007254

GO:0008545

GO:0009408

GO:0009411

GO:0009611

GO:0016301

GO:0016740

GO:0019899

GO:0019901

GO:0019903

GO:0032206

GO:0034612

GO:0043523

GO:0045893

GO:0046330

GO:0046872

GO:0051403

GO:0070374

GO:0071222

GO:0071347

GO:0106310

GO:0140096

GO:2000671

ILMN_1228372

ILMN_2557228

ILMN_3028981

ILMN_3035785

ILMN_3102163

aa254768_at

mMC001887

Participates

as an input of

Phosphorylation of MEK7 by MEKK1 (Mus musculus)

as a member of

MAP2K7,MAP2K4 [cytosol] (Mus musculus)

Other forms of this molecule

phospho-p-S271,T275-MAP2K7 [cytosol]

Inferred From

MAP2K7 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_036074.2, NP_001036022.1, NP_001278707.1, NP_001157644.1, NP_001278706.1, NP_001278712.1

ENSEMBL

ENSMUSP00000106626, ENSMUSP00000106627, ENSMUST00000062686, ENSMUSP00000054512, ENSMUSG00000109061, ENSMUSG00000002948, ENSMUST00000110999, ENSMUSP00000117418, ENSMUST00000110996, ENSMUSP00000003027, ENSMUST00000110998, ENSMUST00000110995, ENSMUST00000003027, ENSMUSP00000106622, ENSMUSP00000106623, ENSMUST00000145165, ENSMUSP00000106624, ENSMUST00000110994

PRO

Q8CE90

MGI

1346871

Cite Us!