Activation of p38 alpha/beta MAPK

Stable Identifier
R-MMU-448961
Type
Reaction [omitted]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of p38 alpha/beta MAPK
p38 alpha/beta MAPK is well established as a promyogenic kinase, but the mechanism by which it is activated during differentiation is not well understood. CDO, JLP and p38 form a ternary complex and it is anticipated that in its role as a scaffold, JLP brings additional components of the pathway, such as MKKs, to these complexes and cooperate to activate p38 alpha/beta MAPK pathway. p38 is activated by phosphorylation on a canonical TxY motif by dual specificity kinases MKK6 and MKK3. MKK6 is the most abundant in skeletal muscles and displays minimal substrate selectivity among all p38 isoforms.
Literature References
PubMed ID Title Journal Year
17074887 Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo

Takaesu, G, Kang, JS, Bae, GU, Yi, MJ, Lee, CM, Reddy, EP, Krauss, RS

J Cell Biol 2006
Participants
Input
Output
Catalyst Activity

MAP kinase kinase activity of Phospho MKK6_MOUSE [cytosol]

Physical Entity
Phospho MKK6_MOUSE [cytosol] (Mus musculus)
Activity
MAP kinase kinase activity (GO:0004708)
Orthologous Events
Activation of p38 alpha/beta MAPK (Homo sapiens)
Authored
Garapati, P V  (2008-08-11)
Reviewed
Krauss, RS  (2010-02-09)
Created
Garapati, P V  (2009-11-26)
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