Activation of p38 alpha/beta MAPK

Stable Identifier
R-HSA-448951
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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p38 alpha/beta MAPK is well established as a promyogenic kinase, but the mechanism by which it is activated during differentiation is not well understood. CDO, JLP and p38 form a ternary complex and it is anticipated that in its role as a scaffold, JLP brings additional components of the pathway, such as MKKs, to these complexes and cooperate to activate p38 alpha/beta MAPK pathway. p38 is activated by phosphorylation on a canonical TxY motif by dual specificity kinases MKK6 and MKK3. MKK6 is the most abundant in skeletal muscles and displays minimal substrate selectivity among all p38 isoforms.
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Participates
Catalyst Activity

MAP kinase kinase activity of p-S207,T211-MAP2K6 [cytosol]

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