Thrombin-activated PAR binds G-protein G12/13

Stable Identifier
R-MMU-427858
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Thrombin-activated PAR binds G-protein G12/13
Thrombin receptors activate G-proteins in the G12/13 family. Gq knockout mice exhibit defective platelet activation, but retain shape change responses to thrombin, mediated by G12/13.
Literature References
PubMed ID Title Journal Year
14528298 G13 is an essential mediator of platelet activation in hemostasis and thrombosis

Offermanns, S, Massberg, S, Gawaz, M, Konrad, I, Simon, MI, Gratacap, MP, Aktas, B, Grüner, S, Moers, A, Wettschureck, N, Nieswandt, B, Schulte, V

Nat Med 2003
Participants
Input
Output
Orthologous Events
Thrombin-activated PARs binds G-protein G12/13 (Homo sapiens)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-06-29)
Cite Us!