Thrombin-activated PAR binds G-protein G12/13

Stable Identifier
R-MMU-427858
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Thrombin-activated PAR binds G-protein G12/13

Thrombin receptors activate G-proteins in the G12/13 family. Gq knockout mice exhibit defective platelet activation, but retain shape change responses to thrombin, mediated by G12/13.

Literature References
PubMed ID Title Journal Year
14528298 G13 is an essential mediator of platelet activation in hemostasis and thrombosis

Moers, A, Nieswandt, B, Massberg, S, Wettschureck, N, GrĂ¼ner, S, Konrad, I, Schulte, V, Aktas, B, Gratacap, MP, Simon, MI, Gawaz, M, Offermanns, S

Nat Med 2003
Participants
Orthologous Events
Authored
Reviewed
Created