Reactome | Nucleosome [nucleoplasm]

Nucleosome [nucleoplasm]

Stable Identifier

R-MMU-427402

Type

Complex

Species

Mus musculus

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Cell-Cell communication (Mus musculus)

- Cell junction organization (Mus musculus)
  - Cell-cell junction organization (Mus musculus)
    - Adherens junctions interactions (Mus musculus)
      - Regulation of Homotypic Cell-Cell Adhesion (Mus musculus)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Mus musculus)
        
        Regulation of CDH1 Expression and Function (Mus musculus)
        
        Regulation of CDH1 Gene Transcription (Mus musculus)
        
        Negative Regulation of CDH1 Gene Transcription (Mus musculus)
        
        PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter (Mus musculus)
        
        PRC2 (EZH2) Core:Nucleosome:CDH1 gene [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)

Chromatin organization (Mus musculus)

- ATP-dependent chromatin remodelers (Mus musculus)
  - CHD chromatin remodelers (Mus musculus)
    - CHD3, CHD4, CHD5 subfamily (Mus musculus)
      - NuRD complex assembly (Mus musculus)
        
        Interaction of NuRD complexes with transcription factors (Mus musculus)
        
        NuRD deacetylates telomeric nucleosomes (Mus musculus)
        
        NR2C2,NR2F2:ZNF827:NuRD:telomeric chromatin [nucleoplasm] (Mus musculus)
        
        Chromatin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- Epigenetic regulation of gene expression (Mus musculus)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Mus musculus)
    - Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Mus musculus)
      - Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Mus musculus)
        
        MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Mus musculus)
        
        RXRA binds ligands (Mus musculus)
        
        PPARG ligands:PPARG:RXRA ligands:RXRA:Corepressors:adipogenesis genes:Nucleosomes [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:ACSL1 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        ACSL1 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:ADIPOQ gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        ADIPOQ gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:AGPAT2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        AGPAT2 gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:ANGPTL4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        ANGPTL4 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:CD36 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        CD36 gene:Nucleosomes [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:CEBPA gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        CEBPA gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:CIDEC gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        CIDEC gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:DGAT2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        DGAT2 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:FABP4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        FABP4 gene:Nucleosomes [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:LIPE gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        LIPE gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:LPIN1 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        LPIN1 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:LPL gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        LPL gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:MGLL gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        MGLL gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PDK4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PDK4 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PEX11A gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PEX11A gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PLIN1 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PLIN1 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PLIN2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PLIN2 gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PLIN4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PLIN4 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PNPLA2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PNPLA2 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:PPARG gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG gene:Nucleosomes [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:Ligand-bound RXRA:NCoR/SMRT:SCD gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        SCD gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound p-Y78,Y102-PPARG2:Ligand-bound RXRA:NCoR/SMRT:ACSS3 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        p-Y78,Y102-PPARG2:RXRA:ACSS3 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        ACSS3 gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound p-Y78,Y102-PPARG2:Ligand-bound RXRA:NCoR/SMRT:ELOVL5 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        p-Y78,Y102-PPARG2:RXRA:ELOVL5 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        ELOVL5 gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound p-Y78,Y102-PPARG2:Ligand-bound RXRA:NCoR/SMRT:GPAM gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        p-Y78,Y102-PPARG2:RXRA:GPAM gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        GPAM gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound p-Y78,Y102-PPARG2:Ligand-bound RXRA:NCoR/SMRT:SCD5 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        p-Y78,Y102-PPARG2:RXRA:SCD5 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        SCD5 gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound p-Y78,Y102-PPARG2:Ligand-bound RXRA:NCoR/SMRT:THRSP gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        p-Y78,Y102-PPARG2:RXRA:THRSP gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        THRSP gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        PPARG ligands:PPARG:RXRA:Corepressors:adipogenesis genes:Nucleosomes [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:ACSL1 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        ACSL1 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:ADIPOQ gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        ADIPOQ gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:AGPAT2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        AGPAT2 gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:ANGPTL4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        ANGPTL4 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:CD36 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        CD36 gene:Nucleosomes [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:CEBPA gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        CEBPA gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:CIDEC gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        CIDEC gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:DGAT2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        DGAT2 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:FABP4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        FABP4 gene:Nucleosomes [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:LIPE gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        LIPE gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:LPIN1 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        LPIN1 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:LPL gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        LPL gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:MGLL gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        MGLL gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PDK4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PDK4 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PEX11A gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PEX11A gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PLIN1 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PLIN1 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PLIN2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PLIN2 gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PLIN4 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PLIN4 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PNPLA2 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PNPLA2 gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:PPARG gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        PPARG gene:Nucleosomes [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound PPARG:RXRA:NCoR/SMRT:SCD gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        SCD gene:Nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound p-Y78,Y102-PPARG2:RXRA:NCoR/SMRT:ACSS3 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        p-Y78,Y102-PPARG2:RXRA:ACSS3 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        ACSS3 gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound p-Y78,Y102-PPARG2:RXRA:NCoR/SMRT:ELOVL5 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        p-Y78,Y102-PPARG2:RXRA:ELOVL5 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        ELOVL5 gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound p-Y78,Y102-PPARG2:RXRA:NCoR/SMRT:GPAM gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        p-Y78,Y102-PPARG2:RXRA:GPAM gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        GPAM gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound p-Y78,Y102-PPARG2:RXRA:NCoR/SMRT:SCD5 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        p-Y78,Y102-PPARG2:RXRA:SCD5 gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        SCD5 gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
        
        Ligand-bound p-Y78,Y102-PPARG2:RXRA:NCoR/SMRT:THRSP gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        p-Y78,Y102-PPARG2:RXRA:THRSP gene:nucleosomes [nucleoplasm] (Mus musculus)
        
        THRSP gene:nucleosome [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
  - PRC2 methylates histones and DNA (Mus musculus)
    - DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Mus musculus)
      - DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Mus musculus)
        
        PRC2 Core:Chromatin [nucleoplasm] (Mus musculus)
        
        Chromatin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
    - PRC2 recruits DNA methyltransferases (Mus musculus)
      - DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Mus musculus)
        
        PRC2 Core:Chromatin [nucleoplasm] (Mus musculus)
        
        Chromatin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
      - PRC2 Core:Chromatin [nucleoplasm] (Mus musculus)
        
        Chromatin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
    - PRC2 trimethylates histone H3 at lysine-27 (Mus musculus)
      - EZHIP:PRC2:Chromatin [nucleoplasm] (Mus musculus)
        
        PRC2:Chromatin [nucleoplasm] (Mus musculus)
        
        Chromatin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
      - PRC2:Chromatin [nucleoplasm] (Mus musculus)
        
        Chromatin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)
  - Regulation of endogenous retroelements (Mus musculus)
    - Regulation of endogenous retroelements by KRAB-ZFP proteins (Mus musculus)
      - SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Mus musculus)
        
        ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm] (Mus musculus)
        
        KRAB-ZFP:retroelement chromatin [nucleoplasm] (Mus musculus)
        
        Retroelement chromatin [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Regulation of T cell activation by CD28 family (Mus musculus)
    - Co-inhibition by PD-1 (Mus musculus)
      - Regulation of PD-L1(CD274) expression (Mus musculus)
        
        Regulation of PD-L1(CD274) transcription (Mus musculus)
        
        Trimethylation of CD274 gene promoter by EZH2 (Mus musculus)
        
        PRC2(EZH2) Core:Nucleosome:CD274 gene promoter [nucleoplasm] (Mus musculus)
        
        Nucleosome [nucleoplasm] (Mus musculus)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a component of

Inferred From

Nucleosome [nucleoplasm] (Homo sapiens)

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