Binding of Acetylcholine by Muscarinic Acetylcholine Receptor M3

Stable Identifier
R-MMU-426560
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Binding of Acetylcholine by Muscarinic Acetylcholine Receptor M3
Intrapancreatic parasympathetic (vagal) nerve endings release acetylcholine during preabsorptive and absorptive phases of feeding. The acetylcholine binds Muscarinic Acetylcholine Receptor M3 on pancreatic islet beta cells (inferred from experiments with knockout mice).
Literature References
PubMed ID Title Journal Year
16753580 A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo

Gautam, D, Han, SJ, Hamdan, FF, Jeon, J, Li, B, Li, JH, Cui, Y, Mears, D, Lu, H, Deng, C, Heard, T, Wess, J

Cell Metab 2006
17919190 Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis

Gautam, D, Han, SJ, Duttaroy, A, Mears, D, Hamdan, FF, Li, JH, Cui, Y, Jeon, J, Wess, J

Diabetes Obes Metab 2007
Participants
Input
Output
Orthologous Events
Acetylcholine binds Muscarinic Acetylcholine Receptor M3 (Homo sapiens)
Authored
May, B  (2009-06-08)
Reviewed
May, B  (2010-05-14)
Created
May, B  (2009-06-17)
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