Recruitment of FAK to NCAM1:Fyn in lipid rafts

Stable Identifier
R-MMU-420394
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Recruitment of FAK to NCAM1:Fyn in lipid rafts

Fyn activation leads to the recruitment and activation of the non-receptor tyrosine kinase FAK. Once recruited to Fyn, FAK undergoes autophosphorylation on tyrosine 397. This tyrosine allows the binding of SH2 domain containing proteins.

Literature References
PubMed ID Title Journal Year
9079653 NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn)

Beggs, HE, Baragona, SC, Hemperly, JJ, Maness, PF

J Biol Chem 1997
Participants
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Focal adhesion kinase 1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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