Recruitment of FAK to NCAM1:Fyn in lipid rafts

Stable Identifier
R-MMU-420394
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Recruitment of FAK to NCAM1:Fyn in lipid rafts
Fyn activation leads to the recruitment and activation of the non-receptor tyrosine kinase FAK. Once recruited to Fyn, FAK undergoes autophosphorylation on tyrosine 397. This tyrosine allows the binding of SH2 domain containing proteins.
Literature References
PubMed ID Title Journal Year
9079653 NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn)

Hemperly, JJ, Baragona, SC, Beggs, HE, Maness, PF

J Biol Chem 1997
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Focal adhesion kinase 1 [cytosol]

Physical Entity
Focal adhesion kinase 1 [cytosol] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Recruitment of FAK to NCAM1:Fyn in lipid rafts (Homo sapiens)
Authored
Garapati, P V  (2009-02-24)
Reviewed
Walmod, PS  (2009-05-26)
Maness, PF  (2009-05-26)
Created
Garapati, P V  (2009-05-11)
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