Reactome | Mrtfa [nucleoplasm]

Mrtfa [nucleoplasm]

Stable Identifier

R-MMU-3900216

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

monoSUMO1-K499,K576,K624-MKL1, Q8K4J6

Locations in the PathwayBrowser for interactor UniProt:P68135 ACTS

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - SUMOylation (Mus musculus)
    - SUMO E3 ligases SUMOylate target proteins (Mus musculus)
      - SUMOylation of transcription cofactors (Mus musculus)
        
        SUMOylation of MKL1 with SUMO1 (Mus musculus)
        
        Mrtfa [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8K4J6

Gene Names

Mrtfa

Reference Genes

BioGPS Gene:223701 Mrtfa

ENSEMBL:ENSMUSG00000042292

KEGG:mmu:223701 Mrtfa

Monarch:223701 Mrtfa

NCBI Gene:223701 Mrtfa

UCSC:Q8K4J6 Mrtfa

Reference Transcript

Other Identifiers

103779_at

10430693

1434900_at

17319429

223701

4355148

4382467

4397449

4418782

4442877

4465893

4484449

4496317

4507677

4565752

4582909

4594769

4671620

4699102

4729651

4906018

4908877

4914140

4946304

4952397

4959956

4984960

4987048

5114290

5142651

5170412

5261834

5377535

5378734

5401613

5469973

5473448

5559622

A_52_P218297

A_55_P1994074

A_55_P2147310

GE102960

GE1489386

GO:0000976

GO:0001764

GO:0003700

GO:0003713

GO:0003779

GO:0003785

GO:0004864

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006357

GO:0008092

GO:0010613

GO:0010667

GO:0030036

GO:0030154

GO:0030838

GO:0030900

GO:0031175

GO:0032967

GO:0043524

GO:0045603

GO:0045666

GO:0045893

GO:0045944

GO:0048856

GO:0048870

GO:0051145

GO:0060090

GO:0061870

GO:0061874

GO:0071300

GO:0071560

GO:0098772

GO:0098793

GO:0098794

GO:0098978

GO:0099159

GO:1904385

GO:1904645

GO:1904899

GO:2000491

GO:2001234

ILMN_1225578

ILMN_1244058

ILMN_2536691

ILMN_2630120

ILMN_2630127

Z31065_s_at

mMC012410

mMR030034

Participates

as an output of

SUMOylation of MKL1 with SUMO1 (Mus musculus)

Other forms of this molecule

Mrtfa [nucleoplasm]

Mrtfa [cytosol]

Inferred From

monoSUMO1-K499,K576,K624-MKL1 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 499 (in Homo sapiens)

Coordinate

499

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 576 (in Homo sapiens)

Coordinate

576

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 624 (in Homo sapiens)

Coordinate

624

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_694629.2, NP_001076005.2

ENSEMBL

ENSMUSP00000105207, ENSMUST00000109579, ENSMUSP00000117745, ENSMUSG00000042292, ENSMUST00000149582

PRO

Q8K4J6

GlyGen

Q8K4J6

MGI

2384495

PDB

2V52, 2V51, 2YJF, 2YJE

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P68135 ACTS			0.558	15
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.525	4
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.525	2