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IGF1,2 [extracellular region]
Stable Identifier
R-MMU-381451
Type
Set [DefinedSet]
Species
Mus musculus
Compartment
extracellular region
Synonyms
Insulin-like Growth Factor
Locations in the PathwayBrowser
Expand all
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Response to elevated platelet cytosolic Ca2+ (Mus musculus)
Platelet degranulation (Mus musculus)
Exocytosis of platelet alpha granule contents (Mus musculus)
Platelet alpha granule contents [extracellular region] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
Metabolism of proteins (Mus musculus)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Mus musculus)
IGFBP1 binds IGF forming IGF:IGFBP1 (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF:IGFBP1 [extracellular region] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGFBP2 binds IGF forming IGF:IGFBP2 (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF:IGFBP2 [extracellular region] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGFBP4 binds IGF forming IGF:IGFBP4 (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF:IGFBP4 [extracellular region] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGFBP6 binds IGF forming IGF:IGFBP6 (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF:IGFBP6 [extracellular region] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
PAAP-A proteolyzes IGF:IGFBP4 (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF:IGFBP4 [extracellular region] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1,2 binds IGF1R (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF1,2:IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF1,2:IGF1R autophosphorylates (Mus musculus)
IGF1,2:IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Mus musculus)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF1,2:p-IGF1R:IRS1,4 [plasma membrane] (Mus musculus)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Mus musculus)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF1,2:p-IGF1R:IRS2 [plasma membrane] (Mus musculus)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Mus musculus)
IGF1,2:p-IGF1R:IRS1,2,4 [plasma membrane] (Mus musculus)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF1,2:p-IGF1R:p-IRS1,2,4 [plasma membrane] (Mus musculus)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
SHC-related events triggered by IGF1R (Mus musculus)
IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Mus musculus)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane] (Mus musculus)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF1R phosphorylates SHC1 (Mus musculus)
IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane] (Mus musculus)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Mus musculus)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
p-3Y-SHC1 dissociates from IGF1R (Mus musculus)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Mus musculus)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Mus musculus)
IGF1,2 [extracellular region] (Mus musculus)
Participants
members
Igf1 [extracellular region] (Mus musculus)
Igf2 [extracellular region] (Mus musculus)
Participant Of
hasMember
Platelet alpha granule contents [extracellular region]
hasComponent
IGF1,2:IGF1R [plasma membrane]
IGF1,2:p-3Y-IGF1R [plasma membrane]
IGF:IGFBP1 [extracellular region]
IGF:IGFBP2 [extracellular region]
IGF:IGFBP4 [extracellular region]
IGF:IGFBP6 [extracellular region]
input
IGF1,2 binds IGF1R
IGFBP1 binds IGF forming IGF:IGFBP1
IGFBP2 binds IGF forming IGF:IGFBP2
IGFBP4 binds IGF forming IGF:IGFBP4
IGFBP6 binds IGF forming IGF:IGFBP6
output
PAAP-A proteolyzes IGF:IGFBP4
Inferred From
IGF1,2 [extracellular region] (Homo sapiens)
Insulin-like growth factors [extracellular region] (Homo sapiens)
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