Reactome | ADCY9 [plasma membrane]

ADCY9 [plasma membrane]

Stable Identifier

R-MMU-379055

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

P51830

Locations in the PathwayBrowser

Expand all

Neuronal System (Mus musculus)

- Transmission across Chemical Synapses (Mus musculus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Mus musculus)
    - GABA receptor activation (Mus musculus)
      - GABA B receptor activation (Mus musculus)
        
        Activation of GABAB receptors (Mus musculus)
        
        Adenylate cyclase inhibitory pathway (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        Dissociation of the Gi alpha:G olf complex (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - DAG and IP3 signaling (Mus musculus)
    - CaM pathway (Mus musculus)
      - Calmodulin induced events (Mus musculus)
        
        PKA-mediated phosphorylation of CREB (Mus musculus)
        
        PKA activation (Mus musculus)
        
        Adenylate cyclase produces cAMP (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (i) signalling events (Mus musculus)
      - Opioid Signalling (Mus musculus)
        
        G-protein mediated events (Mus musculus)
        
        Adenylate cyclase activating pathway (Mus musculus)
        
        Adenylate cyclase converts ATP into cyclic AMP (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        Adenylaye cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        Galpha-olf:GTP binds to adenylate cyclase and activates it (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase inhibitory pathway (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        Dissociation of the Gi alpha:G olf complex (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        PLC beta mediated events (Mus musculus)
        
        Ca-dependent events (Mus musculus)
        
        CaM pathway (Mus musculus)
        
        Calmodulin induced events (Mus musculus)
        
        PKA-mediated phosphorylation of CREB (Mus musculus)
        
        PKA activation (Mus musculus)
        
        Adenylate cyclase produces cAMP (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
    - G alpha (z) signalling events (Mus musculus)
      - G alpha (z) inhibits adenylate cyclase (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)
- Signaling by Hedgehog (Mus musculus)
  - Hedgehog 'off' state (Mus musculus)
    - GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Mus musculus)
      - adenylate cyclases:Mg2+ [plasma membrane] (Mus musculus)
        
        adenylate cyclases [plasma membrane] (Mus musculus)
        
        ADCY9 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P51830

Reference Genes

BioGPS Gene:11515

ENSEMBL:ENSMUSG00000005580

KEGG:mmu:11515

Monarch:11515

NCBI Gene:11515

UCSC:P51830

Reference Transcript

Other Identifiers

10437364

11515

1418586_at

17327720

4439835

4466242

4543584

4545077

4707122

4804860

4806381

4867120

4888513

4935832

5104243

5118774

5332183

5340445

5546347

5556339

5571118

92527_at

A_51_P501538

A_55_P2106666

GE35031

GO:0000166

GO:0001701

GO:0003824

GO:0004016

GO:0005524

GO:0005815

GO:0005829

GO:0005886

GO:0005929

GO:0006171

GO:0007189

GO:0009190

GO:0009975

GO:0016020

GO:0016829

GO:0016849

GO:0030424

GO:0030425

GO:0035556

GO:0036064

GO:0043226

GO:0046872

GO:0048856

GO:0055086

GO:0071880

GO:1901135

ILMN_2723474

mMC017806

u30602_s_at

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Mus musculus)

as a member of

Adenylate cyclase [plasma membrane] (Mus musculus)

Inferred From

ADCY9 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001400202.1, NP_033754.2

ENSEMBL

ENSMUST00000117801, ENSMUSP00000005719, ENSMUSP00000113498, ENSMUST00000005719, ENSMUSG00000005580

IntEnz

4.6.1.1

PRO

P51830

GlyGen

P51830

MGI

108450

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