Reactome | ADCY3 [plasma membrane]

ADCY3 [plasma membrane]

Stable Identifier

R-MMU-379051

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Q8VHH7

Locations in the PathwayBrowser

Expand all

Neuronal System (Mus musculus)

- Transmission across Chemical Synapses (Mus musculus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Mus musculus)
    - GABA receptor activation (Mus musculus)
      - GABA B receptor activation (Mus musculus)
        
        Activation of GABAB receptors (Mus musculus)
        
        Adenylate cyclase inhibitory pathway (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        Dissociation of the Gi alpha:G olf complex (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - DAG and IP3 signaling (Mus musculus)
    - CaM pathway (Mus musculus)
      - Calmodulin induced events (Mus musculus)
        
        PKA-mediated phosphorylation of CREB (Mus musculus)
        
        PKA activation (Mus musculus)
        
        Adenylate cyclase produces cAMP (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (i) signalling events (Mus musculus)
      - Opioid Signalling (Mus musculus)
        
        G-protein mediated events (Mus musculus)
        
        Adenylate cyclase activating pathway (Mus musculus)
        
        Adenylate cyclase converts ATP into cyclic AMP (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        Adenylaye cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        Galpha-olf:GTP binds to adenylate cyclase and activates it (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase inhibitory pathway (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        Dissociation of the Gi alpha:G olf complex (Mus musculus)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Mus musculus)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        PLC beta mediated events (Mus musculus)
        
        Ca-dependent events (Mus musculus)
        
        CaM pathway (Mus musculus)
        
        Calmodulin induced events (Mus musculus)
        
        PKA-mediated phosphorylation of CREB (Mus musculus)
        
        PKA activation (Mus musculus)
        
        Adenylate cyclase produces cAMP (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
    - G alpha (z) signalling events (Mus musculus)
      - G alpha (z) inhibits adenylate cyclase (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Mus musculus)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Mus musculus)
        
        Adenylate cyclase [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)
- Signaling by Hedgehog (Mus musculus)
  - Hedgehog 'off' state (Mus musculus)
    - GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Mus musculus)
      - adenylate cyclases:Mg2+ [plasma membrane] (Mus musculus)
        
        adenylate cyclases [plasma membrane] (Mus musculus)
        
        ADCY3 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8VHH7 Adcy3

Gene Names

Adcy3

Chain

chain:1-1145

Reference Genes

BioGPS Gene:104111 Adcy3

KEGG:mmu:104111 Adcy3

Monarch:104111 Adcy3

NCBI Gene:104111 Adcy3

UCSC:Q8VHH7 Adcy3

Reference Transcript

Other Identifiers

10394258

104111

1421959_s_at

1421960_at

1436928_s_at

160870_at

17273714

4440327

4472181

4488833

4557859

4598087

4604787

4643981

4691830

4815685

4857734

4881406

4886447

4916012

4918258

4937874

4939758

4971004

5001939

5006092

5016576

5036176

5060465

5151217

5266480

5310886

5313683

5332593

5392667

5466909

5502608

5543333

5599853

A_51_P484671

A_52_P216525

GE128819

GO:0000166

GO:0003824

GO:0004016

GO:0005515

GO:0005516

GO:0005524

GO:0005737

GO:0005794

GO:0005886

GO:0005929

GO:0006171

GO:0007018

GO:0007189

GO:0007338

GO:0007340

GO:0007608

GO:0008355

GO:0009190

GO:0009975

GO:0016020

GO:0016829

GO:0016849

GO:0022414

GO:0030317

GO:0035556

GO:0042995

GO:0043226

GO:0046872

GO:0048870

GO:0050877

GO:0055086

GO:0060170

GO:1901135

GO:1904322

ILMN_1246656

ILMN_1246856

ILMN_2502641

ILMN_2666118

Msa.33702.0_s_at

mMC005970

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Mus musculus)

as a member of

Adenylate cyclase [plasma membrane] (Mus musculus)

Other forms of this molecule

Adcy3 [plasma membrane]

Inferred From

ADCY3 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_006514998.1, XP_006514997.1, NP_001409715.1, NP_612178.2

ENSEMBL

ENSMUST00000020984, ENSMUSG00000020654, ENSMUSP00000115406, ENSMUST00000127756, ENSMUSP00000020984

PRO

Q8VHH7

GlyGen

Q8VHH7

MGI

99675

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