Reactome | ADCY3 [plasma membrane]

ADCY3

Stable Identifier

R-HSA-379051

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Adenylate cyclase type 3, ADCY3_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptor and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
        
        Activation of Adenylate Cyclase (Homo sapiens)
        
        Ca/calmodulin activated Adenylate Cyclase [plasma membrane] (Homo sapiens)
        
        ADCY3 [plasma membrane] (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Inhibition of adenylate cyclase pathway (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY3 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY3 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY3 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY3 [plasma membrane] (Homo sapiens)
        
        Dissociation of the Gi alpha:G olf complex (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY3 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY3 [plasma membrane] (Homo sapiens)
        
        G alpha (i) inhibits adenylate cyclase (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY3 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY3 [plasma membrane] (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY3 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        ADCY3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60266 ADCY3

Gene Names

ADCY3, KIAA0511

Chain

chain:1-1144

Reference Genes

BioGPS Gene:109 ADCY3

COSMIC (genes):ADCY3 ADCY3

CTD Gene:109 ADCY3

dbSNP Gene:109 ADCY3

ENSEMBL:ENSG00000138031 ADCY3

HGNC:234 ADCY3

KEGG Gene (Homo sapiens):hsa:109 ADCY3

Monarch:109 ADCY3

NCBI Gene:109 ADCY3

OMIM:600291 ADCY3

UCSC:O60266 ADCY3

Reference Transcript

Other Identifiers

0003710008

00230+4.6.1.1

10223

109

11716872_a_at

16895278

209320_at

209321_s_at

2544485

2544486

2544490

2544491

2544498

2544501

2544502

2544505

2544506

2544507

2544508

2544511

2544515

2544516

2544517

2544518

2544519

2544521

2544522

2544523

2544524

2544536

2544551

2544552

2544553

2544554

2544555

2544556

2544557

33134_at

8050766

A_23_P67864

AAD13403

AAI26236

AAY14787

AB011083

AC012073

ADCY3

ADCY3-201

AF033861

AK095173

BAA25437

BAG52998

BC126235

CAB010223

CCDS1715

ENSG00000138031

ENSP00000260600

ENST00000260600

EntrezGene:109

g4104225_3p_at

GE54256

GO:0000003

GO:0000166

GO:0003091

GO:0003674

GO:0004016

GO:0004383

GO:0005516

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0005887

GO:0005929

GO:0006171

GO:0006182

GO:0006464

GO:0007165

GO:0007186

GO:0007189

GO:0007190

GO:0007193

GO:0007338

GO:0007340

GO:0007608

GO:0008074

GO:0008150

GO:0008355

GO:0009058

GO:0009190

GO:0016020

GO:0016021

GO:0016829

GO:0016849

GO:0030317

GO:0034199

GO:0034641

GO:0035556

GO:0040011

GO:0042592

GO:0042995

GO:0043167

GO:0043226

GO:0043234

GO:0044281

GO:0046872

GO:0048870

GO:0050877

GO:0050896

GO:0071377

GO:1904322

HGNC:234

ILMN_1676893

IPR001054

IPR018297

IPR029787

IPR030672

IPR032628

MIM:600291

NM_004036

NP_004027

PF00211

PF16214

PH_hs_0022898

SM00044

TC02001653.hg

uc002rfs.5

UPI000013D0ED

XM_011532490

XM_011532494

XM_017003186

XM_017003187

XM_017003188

XM_017003189

XM_017003190

XM_017003193

XP_011530792

XP_011530796

XP_016858675

XP_016858676

XP_016858677

XP_016858678

XP_016858679

XP_016858682

Participant Of

hasCandidate

adenylate cyclases [plasma membrane]

hasMember

Inferred To

Homologues of ADCY3 [plasma membrane] (Canis familiaris)

Homologues of ADCY3 [plasma membrane] (Danio rerio)

Homologues of ADCY3 [plasma membrane] (Drosophila melanogaster)

Homologues of ADCY3 [plasma membrane] (Gallus gallus)

Homologues of ADCY3 [plasma membrane] (Sus scrofa)

Homologues of ADCY3 [plasma membrane] (Xenopus tropicalis)

ADCY3 [plasma membrane] (Bos taurus)

ADCY3 [plasma membrane] (Canis familiaris)

ADCY3 [plasma membrane] (Danio rerio)

ADCY3 [plasma membrane] (Dictyostelium discoideum)

ADCY3 [plasma membrane] (Drosophila melanogaster)

ADCY3 [plasma membrane] (Gallus gallus)

ADCY3 [plasma membrane] (Mus musculus)

ADCY3 [plasma membrane] (Rattus norvegicus)

ADCY3 [plasma membrane] (Sus scrofa)

ADCY3 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_004027.2, NP_001307542.1

GeneCards

O60266

PRO

O60266

BRENDA (Homo sapiens)

4.6.1.1

HMDB Protein

HMDBP00710