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Usp7 [nucleoplasm]
Stable Identifier
R-MMU-3215278
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
USP7, Q6A4J8
Locations in the PathwayBrowser
Expand all
DNA Repair (Mus musculus)
Nucleotide Excision Repair (Mus musculus)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Mus musculus)
Dual incision in TC-NER (Mus musculus)
3' incision by ERCC5 (XPG) in TC-NER (Mus musculus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Mus musculus)
TC-NER incision complex [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Mus musculus)
TC-NER incision complex [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Mus musculus)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
TC-NER pre-incision complex [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
ERCC5 and RPA bind TC-NER site (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
Formation of TC-NER Pre-Incision Complex (Mus musculus)
Assembly of the pre-incision complex in TC-NER (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)
TC-NER pre-incision complex [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
Gap-filling DNA repair synthesis and ligation in TC-NER (Mus musculus)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Mus musculus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Mus musculus)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
Regulation of TP53 Activity (Mus musculus)
Regulation of TP53 Expression and Degradation (Mus musculus)
Regulation of TP53 Degradation (Mus musculus)
DAXX binds Ub-MDM2 and USP7 (Mus musculus)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
USP7 deubiquitinates MDM2 (Mus musculus)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
USP7 deubiquitinates TP53 and counteracts MDM2 (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ub-specific processing proteases (Mus musculus)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Mus musculus)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
PTEN Regulation (Mus musculus)
Regulation of PTEN localization (Mus musculus)
USP7 deubiquitinates monoubiquitinated PTEN (Mus musculus)
Usp7 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q6A4J8
Gene Names
Usp7
Reference Genes
BioGPS Gene:252870 Usp7
ENSEMBL:ENSMUSG00000022710
KEGG:mmu:252870 Usp7
Monarch:252870 Usp7
NCBI Gene:252870 Usp7
UCSC:Q6A4J8 Usp7
Reference Transcript
RefSeq:NM_001003918.2 Usp7
Participates
as a component of
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Mus musculus)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Mus musculus)
UVSSA:USP7 [nucleoplasm] (Mus musculus)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Mus musculus)
as an output of
USP7 deubiquitinates MDM2 (Mus musculus)
as an input of
DAXX binds Ub-MDM2 and USP7 (Mus musculus)
Other forms of this molecule
Usp7 [cytosol]
Inferred From
USP7 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001003918.2
PRO
Q6A4J8
GlyGen
Q6A4J8
MGI
2182061
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