Reactome | Dusp6 [nucleoplasm]

Dusp6 [nucleoplasm]

Stable Identifier

R-MMU-2871619

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

DUSP6, Q9DBB1

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-17 signaling (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        Dusp6 [nucleoplasm] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        Dusp6 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        Dusp6 [nucleoplasm] (Mus musculus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        Dusp6 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        Dusp6 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        Dusp6 [nucleoplasm] (Mus musculus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        Dusp6 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        Dusp6 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        Dusp6 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        Dusp6 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by NTRKs (Mus musculus)
    - Signaling by NTRK1 (TRKA) (Mus musculus)
      - Nuclear Events (kinase and transcription factor activation) (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERKs are inactivated (Mus musculus)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)
        
        ERK-specific DUSP [nucleoplasm] (Mus musculus)
        
        Dusp6 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9DBB1

Gene Names

Dusp6

Reference Genes

BioGPS Gene:67603 Dusp6

ENSEMBL:ENSMUSG00000019960

KEGG:mmu:67603 Dusp6

Monarch:67603 Dusp6

NCBI Gene:67603 Dusp6

UCSC:Q9DBB1 Dusp6

Reference Transcript

RefSeq:NM_026268.3 Dusp6

Other Identifiers

10366043

107433_at

1415834_at

17236882

4351143

4445992

4478558

4562143

4578453

4630021

4806403

5018000

5103711

5189301

5519227

5569499

67603

93285_at

A_30_P01021895

A_51_P502614

GE41465

GO:0003824

GO:0004721

GO:0004722

GO:0004725

GO:0005515

GO:0005654

GO:0005737

GO:0005829

GO:0006470

GO:0007165

GO:0008138

GO:0008330

GO:0009410

GO:0016311

GO:0016787

GO:0017017

GO:0030154

GO:0033550

GO:0043065

GO:0043409

GO:0051409

GO:0060420

GO:0070373

GO:0070848

GO:0140096

ILMN_1248537

ILMN_2701321

ILMN_2925711

aa184871_s_at

mMC011102

Participates

as a member of

ERK-specific DUSP [nucleoplasm] (Mus musculus)

Other forms of this molecule

Dusp6 [cytosol]

Inferred From

DUSP6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_080544.1

ENSEMBL

ENSMUSP00000020118, ENSMUST00000020118, ENSMUSG00000019960

IntEnz

3.1.3.48

PRO

Q9DBB1

MGI

1914853

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63085 Mapk1	9	MAPK1 [ficolin-1-rich granule lumen] (R-MMU-6800964) MAPK1 [extracellular region] (R-MMU-6806250) MAPK1 [azurophil granule lumen] (R-MMU-6799225) phospho-p-T185-MAPK1 [cytosol] (R-MMU-9635773) p-T183,Y185-Mapk1 [nucleoplasm] (R-MMU-198682) MAPK1 [nucleoplasm] (R-MMU-199960) MAPK1 [cytosol] (R-MMU-59282) phospho-p-T185,Y187-MAPK1 [cytosol] (R-MMU-109853) phospho-p-T185,Y187-MAPK1 [nucleoplasm] (R-MMU-112354)	0.508	2

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