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MAPK1 [cytosol]
Stable Identifier
R-MMU-59282
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P63085
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
L1CAM interactions (Mus musculus)
Signal transduction by L1 (Mus musculus)
MAP2K2 phosphorylates MAPK1 (Mus musculus)
p-S,T-MAP2K2:MAPK1 [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Thrombin signalling through proteinase activated receptors (PARs) (Mus musculus)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Mus musculus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
F2R:ARRB1 binds MAPKs, SRC-1 (Mus musculus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
F2R:ARRB2 binds MAPKs, SRC-1 (Mus musculus)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
SRC-1 bound to ARRB2 is not activated (Mus musculus)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Mus musculus)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Growth hormone receptor signaling (Mus musculus)
Lyn activates ERK (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
Interferon Signaling (Mus musculus)
Interferon gamma signaling (Mus musculus)
IFNG signaling activates MAPKs (Mus musculus)
JAK1-activated RAF1 phosphorylates MAPKs (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF-independent MAPK1/3 activation (Mus musculus)
Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)
MAPK monomers and dimers [cytosol] (Mus musculus)
MAPK1 dimer [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
MAPK1 (ERK2) activation (Mus musculus)
MAP2K2 binds MAPK1 (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
p-S,T-MAP2K2:MAPK1 [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
MAP2K2 phosphorylates MAPK1 (Mus musculus)
p-S,T-MAP2K2:MAPK1 [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
MAP2K and MAPK activation (Mus musculus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
IL17RD binds p-2S MAP2Ks and MAPKs (Mus musculus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Mus musculus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Mus musculus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
MAP2Ks phosphorylate MAPKs (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
RAF phosphorylates MAP2K dimer (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
Negative regulation of MAPK pathway (Mus musculus)
Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)
MAPK monomers and dimers [cytosol] (Mus musculus)
MAPK1 dimer [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
Signal attenuation (Mus musculus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Mus musculus)
MAPK3,(MAPK1) [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Mus musculus)
MAPK3,(MAPK1) [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
Signalling to ERKs (Mus musculus)
Prolonged ERK activation events (Mus musculus)
Frs2-mediated activation (Mus musculus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Mus musculus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Mus musculus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
MAPKs [cytosol] (Mus musculus)
MAPK1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P63085 Mapk1
Gene Names
Mapk1, Erk2, Mapk, Prkm1
Chain
initiator methionine:, chain:2-358
Reference Genes
BioGPS Gene:26413 Mapk1
ENSEMBL:ENSMUSG00000063358.18 Mapk1
KEGG Gene (Mus musculus):26413 Mapk1
Monarch:26413 Mapk1
NCBI Gene:26413 Mapk1
UCSC:P63085 Mapk1
Reference Transcript
RefSeq:XM_006522147.3 Mapk1
RefSeq:NM_001038663.1 Mapk1
RefSeq:NM_011949.3 Mapk1
Other Identifiers
10433940
113275_at
1419568_at
1426585_s_at
1432356_at
1453104_at
17323371
17323387
26413
4404274
4575774
4579040
4640098
4657032
4737861
4891855
4944925
5090069
5104720
5201399
5208266
5252009
5322602
5369243
5477087
5586880
93253_at
93254_at
A_51_P263503
A_51_P481788
A_52_P100088
A_52_P352512
A_55_P1973334
A_55_P1973339
A_55_P1977548
A_65_P02960
GE1515219
GE40226
GE42701
GO:0000165
GO:0000166
GO:0001784
GO:0002376
GO:0003677
GO:0003690
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005794
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005901
GO:0005925
GO:0006351
GO:0006355
GO:0006357
GO:0006468
GO:0006886
GO:0006913
GO:0006915
GO:0006974
GO:0007010
GO:0007049
GO:0007166
GO:0007507
GO:0008286
GO:0008353
GO:0009636
GO:0009887
GO:0010759
GO:0010800
GO:0012501
GO:0014032
GO:0014044
GO:0014069
GO:0015966
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0019233
GO:0019858
GO:0019901
GO:0019902
GO:0022414
GO:0023052
GO:0030154
GO:0030278
GO:0030424
GO:0030521
GO:0030641
GO:0030878
GO:0031143
GO:0031410
GO:0031435
GO:0031647
GO:0031663
GO:0032200
GO:0032212
GO:0032496
GO:0032839
GO:0032872
GO:0032991
GO:0033598
GO:0034198
GO:0034614
GO:0035094
GO:0035556
GO:0036211
GO:0038127
GO:0038133
GO:0042307
GO:0042473
GO:0042552
GO:0042802
GO:0043204
GO:0043226
GO:0043330
GO:0043401
GO:0043627
GO:0045596
GO:0045727
GO:0045893
GO:0046697
GO:0048009
GO:0048538
GO:0048856
GO:0048870
GO:0050847
GO:0050852
GO:0050853
GO:0050877
GO:0051090
GO:0051403
GO:0051493
GO:0055086
GO:0060020
GO:0060045
GO:0060291
GO:0060324
GO:0060425
GO:0060440
GO:0060716
GO:0061308
GO:0070161
GO:0070371
GO:0070849
GO:0071276
GO:0071310
GO:0071356
GO:0072584
GO:0072686
GO:0090170
GO:0106310
GO:0120041
GO:0140096
GO:1904355
GO:2000641
ILMN_1213055
ILMN_1232775
ILMN_1250643
ILMN_2601071
ILMN_2649828
aa242333_s_at
d10939_s_at
mMC021802
mMC024552
mMR029925
Participates
as a candidate of
MAPK3,(MAPK1) [cytosol] (Mus musculus)
as a component of
MAPK1 dimer [cytosol] (Mus musculus)
p-S,T-MAP2K2:MAPK1 [cytosol] (Mus musculus)
as an input of
MAP2K2 binds MAPK1 (Mus musculus)
as a member of
MAPKs [cytosol] (Mus musculus)
Other forms of this molecule
phospho-p-T185,Y187-MAPK1 [nucleoplasm]
phospho-p-T185,Y187-MAPK1 [cytosol]
MAPK1 [nucleoplasm]
p-T183,Y185-Mapk1 [nucleoplasm]
phospho-p-T185-MAPK1 [cytosol]
MAPK1 [ficolin-1-rich granule lumen]
MAPK1 [extracellular region]
MAPK1 [azurophil granule lumen]
Inferred From
MAPK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006522210.1
,
NP_001033752.1
,
NP_036079.1
ZINC - Substances
MK01_MOUSE
Ensembl
ENSMUSP00000111396
,
ENSMUST00000115731
,
ENSMUSG00000063358
,
ENSMUSP00000156154
,
ENSMUSP00000065983
,
ENSMUST00000069107
,
ENSMUST00000232611
ZINC target
P63085
PRO
P63085
ZINC - Predictions - Purchasable
MK01_MOUSE
MGI
1346858
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q62132 PTPRR
0.704
5
UniProt:P63085 Mapk1
9
phospho-p-T185,Y187-MAPK1 [nucleoplasm]
(R-MMU-112354)
phospho-p-T185,Y187-MAPK1 [cytosol]
(R-MMU-109853)
MAPK1 [cytosol]
(R-MMU-59282)
MAPK1 [nucleoplasm]
(R-MMU-199960)
p-T183,Y185-Mapk1 [nucleoplasm]
(R-MMU-198682)
phospho-p-T185-MAPK1 [cytosol]
(R-MMU-9635773)
MAPK1 [ficolin-1-rich granule lumen]
(R-MMU-6800964)
MAPK1 [extracellular region]
(R-MMU-6806250)
MAPK1 [azurophil granule lumen]
(R-MMU-6799225)
0.631
5
UniProt:Q62108 Dlg4
3
SAP-90 [plasma membrane]
(R-MMU-443606)
Dlg4 [endocytic vesicle membrane]
(R-MMU-416847)
Dlg4 [cytosol]
(R-MMU-6794267)
0.623
4
UniProt:A0A0F6AZL3 A0A0F6AZL3
0.576
3
UniProt:G3G926 G3G926
0.567
8
UniProt:O95863 SNAI1
1
SNAI1 [nucleoplasm]
(R-HSA-2980903)
0.544
3
ChEBI:90905 DEL-22379
0.524
2
UniProt:Q9DBB1
2
Dusp6 [cytosol]
(R-MMU-5675343)
Dusp6 [nucleoplasm]
(R-MMU-2871619)
0.508
2
UniProt:P23441 NKX21
0.502
2
UniProt:P35438 Grin1
3
Grin1 [plasma membrane]
(R-MMU-3928395)
Grin1 [endoplasmic reticulum membrane]
(R-MMU-9610359)
Grin1 [transport vesicle membrane]
(R-MMU-9610566)
0.462
2
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