Clcn3 exchanges Cl- for H+

Stable Identifier
R-MMU-2730951
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, endosome lumen, endosome membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Clcn3 exchanges Cl- for H+
The murine H+/Cl- exchange transporter Clcn3 mediates the exchange of endosomal Cl- for cytosolic H+ across late endosomal membranes, contributing to the acidification of endosomes (Borsani et al. 1995, Stobrawa et al. 2001, Hara-Chikuma et al. 2005).
Literature References
PubMed ID Title Journal Year
11182090 Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus

Stobrawa, SM, Breiderhoff, T, Takamori, S, Engel, D, Schweizer, M, Zdebik, AA, Bösl, MR, Ruether, K, Jahn, H, Draguhn, A, Jahn, R, Jentsch, TJ

Neuron 2001
15504734 ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation

Hara-Chikuma, M, Yang, B, Sonawane, ND, Sasaki, S, Uchida, S, Verkman, AS

J. Biol. Chem. 2005
7665160 Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein

Borsani, G, Rugarli, EI, Taglialatela, M, Wong, C, Ballabio, A

Genomics 1995
Participants
Input
Output
Catalyst Activity

antiporter activity of Clcn3 [late endosome membrane]

Physical Entity
Clcn3 [late endosome membrane] (Mus musculus)
Activity
antiporter activity (GO:0015297)
Orthologous Events
CLCN3 exchanges Cl- for H+ (Homo sapiens)
Authored
Jassal, B  (2012-12-05)
Reviewed
He, L  (2013-01-28)
Created
Jassal, B  (2012-12-05)
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