Clcn3 exchanges Cl- for H+

Stable Identifier
R-MMU-2730951
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, endosome lumen, endosome membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Clcn3 exchanges Cl- for H+
The murine H+/Cl- exchange transporter Clcn3 mediates the exchange of endosomal Cl- for cytosolic H+ across late endosomal membranes, contributing to the acidification of endosomes (Borsani et al. 1995, Stobrawa et al. 2001, Hara-Chikuma et al. 2005).
Literature References
PubMed ID Title Journal Year
11182090 Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus

Ruether, K, Zdebik, AA, Bösl, MR, Jentsch, TJ, Jahn, H, Jahn, R, Schweizer, M, Draguhn, A, Takamori, S, Stobrawa, SM, Engel, D, Breiderhoff, T

Neuron 2001
15504734 ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation

Uchida, S, Hara-Chikuma, M, Yang, B, Sasaki, S, Sonawane, ND, Verkman, AS

J. Biol. Chem. 2005
7665160 Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein

Taglialatela, M, Ballabio, A, Rugarli, EI, Wong, C, Borsani, G

Genomics 1995
Participants
Input
Output
Catalyst Activity

antiporter activity of Clcn3 [late endosome membrane]

Physical Entity
Clcn3 [late endosome membrane] (Mus musculus)
Activity
antiporter activity (GO:0015297)
Orthologous Events
CLCN3 exchanges Cl- for H+ (Homo sapiens)
Authored
Jassal, B  (2012-12-05)
Reviewed
He, L  (2013-01-28)
Created
Jassal, B  (2012-12-05)
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