Phosphorylation of Gab2 by Syk/Fyn

Stable Identifier
R-MMU-2730869
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of Gab2 by Syk/Fyn
GAB2 have multiple tyrosyl phosphorylation sites that are phosphorylated up on activation of FCERI. SYK is the major tyrosine kinase involved in GAB2 phosphorylation. FYN is also shown to contribute to GAB2 tyrosyl phosphorylation but it is not clear whether GAB2 is a direct substrate of FYN (Yu et al. 2006, Parravicini et al. 2002). GAB2 tyrosines (Y452, Y476 and Y584) in the YXXM motif can be the target phosphorylation sites for SYK/FYN kinases (Chan et al. 2010, Harir et al. 2007).
Literature References
PubMed ID Title Journal Year
12089510 Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

Parravicini, V, Gadina, M, Kovarova, M, Odom, S, Gonzalez-Espinosa, C, Furumoto, Y, Saitoh, S, Samelson, LE, O'Shea, JJ, Rivera, J

Nat. Immunol. 2002
16456001 Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI

Yu, M, Lowell, CA, Neel, BG, Gu, H

J. Immunol. 2006
Participants
Input
Output
Orthologous Events
Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-05)
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