Phosphorylation of GAB2 by SYK/FYN

Stable Identifier
R-HSA-2730860
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Phosphorylation of GAB2 by SYK/FYN
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GAB2 have multiple tyrosyl phosphorylation sites that are phosphorylated up on activation of FCERI. SYK is the major tyrosine kinase involved in GAB2 phosphorylation. FYN is also shown to contribute to GAB2 tyrosyl phosphorylation but it is not clear whether GAB2 is a direct substrate of FYN (Yu et al. 2006, Parravicini et al. 2002). GAB2 tyrosines (Y452, Y476 and Y584) in the YXXM motif can be the target phosphorylation sites for SYK/FYN kinases (Chan et al. 2010, Harir et al. 2007).
Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of SYK/FYN [plasma membrane]

Physical Entity
SYK/FYN [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Phosphorylation of Gab2 by Syk/Fyn (Mus musculus)
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-05)
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