Phosphorylated Lepr Binds Stat3

Stable Identifier
R-MMU-2671854
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated Lepr Binds Stat3
Stat3 binds phosphotyrosine-1138 of Lepr. Stat3 activation by Lepr is required in the hypothalamus for acute reduction of food intake (Buettner et al. 2006).
Literature References
PubMed ID Title Journal Year
16814732 Critical role of STAT3 in leptin's metabolic actions

Rossetti, L, Buettner, C, Pocai, A, Muse, ED, Etgen, AM, Myers, MG

Cell Metab. 2006
9003804 Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130

Narazaki, M, Nakashima, K, Taga, T

FEBS Lett. 1997
8782827 Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

Horvath, CM, Stoffel, M, Vaisse, C, Halaas, JL, Friedman, JM, Darnell, JE

Nat. Genet. 1996
15634336 Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines

Bamberg-Lemper, S, Knobelspies, H, Joost, HG, Lavens, D, Hekerman, P, Tavernier, J, Becker, W, Zeidler, J

FEBS J. 2005
Participants
Input
Output
Orthologous Events
Phosphorylated LEPR Binds STAT3 (Homo sapiens)
Authored
May, B  (2012-11-24)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-26)
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