Phosphorylated Lepr Binds Stat3

Stable Identifier
R-MMU-2671854
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Phosphorylated Lepr Binds Stat3

Stat3 binds phosphotyrosine-1138 of Lepr. Stat3 activation by Lepr is required in the hypothalamus for acute reduction of food intake (Buettner et al. 2006).

Literature References
PubMed ID Title Journal Year
9003804 Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130

Nakashima, K, Narazaki, M, Taga, T

FEBS Lett. 1997
16814732 Critical role of STAT3 in leptin's metabolic actions

Buettner, C, Pocai, A, Muse, ED, Etgen, AM, Myers, MG, Rossetti, L

Cell Metab. 2006
8782827 Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

Vaisse, C, Halaas, JL, Horvath, CM, Darnell, JE, Stoffel, M, Friedman, JM

Nat. Genet. 1996
15634336 Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines

Hekerman, P, Zeidler, J, Bamberg-Lemper, S, Knobelspies, H, Lavens, D, Tavernier, J, Joost, HG, Becker, W

FEBS J. 2005
Participants
Orthologous Events
Authored
Reviewed
Created