Phosphorylated LEPR Binds STAT3

Stable Identifier
R-HSA-2671868
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Phosphorylated LEPR Binds STAT3
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STAT3 binds phosphotyrosine-1141 of the C-terminal, cytoplasmic region of LEPR (Bjorbaek et al. 1997). Only the long isoform of LEPR has tyrosine-1141 and consequently only the long isoform of LEPR activates STAT3. Short isoforms of LEPR exist but their function is uncertain. Shorter LEPR isoforms bind JAK2 and can signal through IRS-1 or ERKs, including MAPKs (Bjorbaek et al. 1997).
Literature References
PubMed ID Title Journal Year
9405487 Divergent signaling capacities of the long and short isoforms of the leptin receptor

da Silva, B, Uotani, S, Flier, JS, Bjørbaek, C

J. Biol. Chem. 1997
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Inferred From
Phosphorylated Lepr Binds Stat3 (Mus musculus)
Authored
May, B  (2012-11-15)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-26)
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