Jak2 Phosphorylates Stat3 in Response to Leptin

Stable Identifier
R-MMU-2671836
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Jak2 Phosphorylates Stat3 in Response to Leptin
Phosphorylated Jak2 phosphorylates tyrosine-705 of Stat3 in the Lep:Lepr:Jak2:Stat3 complex.
Literature References
PubMed ID Title Journal Year
9003804 Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130

Nakashima, K, Narazaki, M, Taga, T

FEBS Lett. 1997
8782827 Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

Vaisse, C, Halaas, JL, Horvath, CM, Darnell, JE, Stoffel, M, Friedman, JM

Nat. Genet. 1996
10799542 Activation of downstream signals by the long form of the leptin receptor

Banks, AS, Davis, SM, Bates, SH, Myers, MG

J. Biol. Chem. 2000
15634336 Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines

Hekerman, P, Zeidler, J, Bamberg-Lemper, S, Knobelspies, H, Lavens, D, Tavernier, J, Joost, HG, Becker, W

FEBS J. 2005
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Lep:p-Lepr:p-Jak2:Stat3 [plasma membrane]

Physical Entity
Lep:p-Lepr:p-Jak2:Stat3 [plasma membrane] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
JAK2 Phosphoryates STAT3 in Response to Leptin (Homo sapiens)
Authored
May, B  (2012-11-24)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-26)
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