Jak2 Phosphorylates Stat3 in Response to Leptin

Stable Identifier
R-MMU-2671836
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Jak2 Phosphorylates Stat3 in Response to Leptin

Phosphorylated Jak2 phosphorylates tyrosine-705 of Stat3 in the Lep:Lepr:Jak2:Stat3 complex.

Literature References
PubMed ID Title Journal Year
8782827 Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

Vaisse, C, Halaas, JL, Horvath, CM, Darnell, JE, Stoffel, M, Friedman, JM

Nat. Genet. 1996
9003804 Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130

Nakashima, K, Narazaki, M, Taga, T

FEBS Lett. 1997
10799542 Activation of downstream signals by the long form of the leptin receptor

Banks, AS, Davis, SM, Bates, SH, Myers, MG

J. Biol. Chem. 2000
15634336 Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines

Hekerman, P, Zeidler, J, Bamberg-Lemper, S, Knobelspies, H, Lavens, D, Tavernier, J, Joost, HG, Becker, W

FEBS J. 2005
Participants
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Lep:p-Lepr:p-Jak2:Stat3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created