Reactome | Lmna [nucleoplasm]

Lmna [nucleoplasm]

Stable Identifier

R-MMU-264866

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Lamin A, P48678

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Nuclear Envelope (NE) Reassembly (Mus musculus)
        
        Initiation of Nuclear Envelope (NE) Reformation (Mus musculus)
        
        BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Mus musculus)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Mus musculus)
        
        Lamin filaments [nucleoplasm] (Mus musculus)
        
        Lamin dimers [nucleoplasm] (Mus musculus)
        
        Lamin A dimer [nucleoplasm] (Mus musculus)
        
        Lmna [nucleoplasm] (Mus musculus)
    - Mitotic Prophase (Mus musculus)
      - Nuclear Envelope Breakdown (Mus musculus)
        
        Depolymerization of the Nuclear Lamina (Mus musculus)
        
        Depolymerization of lamin filaments after PKC-mediated phosphorylation (Mus musculus)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Mus musculus)
        
        Lamin filaments [nucleoplasm] (Mus musculus)
        
        Lamin dimers [nucleoplasm] (Mus musculus)
        
        Lamin A dimer [nucleoplasm] (Mus musculus)
        
        Lmna [nucleoplasm] (Mus musculus)
        
        VRK1/VRK2 phosphorylate BANF1 (Mus musculus)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Mus musculus)
        
        Lamin filaments [nucleoplasm] (Mus musculus)
        
        Lamin dimers [nucleoplasm] (Mus musculus)
        
        Lamin A dimer [nucleoplasm] (Mus musculus)
        
        Lmna [nucleoplasm] (Mus musculus)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Mus musculus)
        
        Lamin filaments [nucleoplasm] (Mus musculus)
        
        Lamin dimers [nucleoplasm] (Mus musculus)
        
        Lamin A dimer [nucleoplasm] (Mus musculus)
        
        Lmna [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P48678 Lmna

Gene Names

Lmna, Lmn1

Chain

chain:1-662, chain:1-647, propeptide:648-662, propeptide:663-665

Reference Genes

BioGPS Gene:16905 Lmna

KEGG:mmu:16905 Lmna

Monarch:16905 Lmna

NCBI Gene:16905 Lmna

UCSC:P48678 Lmna

Reference Transcript

Participates

as a component of

Lamin A dimer [nucleoplasm] (Mus musculus)

as an input of

Caspase-mediated cleavage of Lamin A (Mus musculus)

Other forms of this molecule

phospho-Lmna [nucleoplasm]

Lmna [nucleoplasm]

Lmna [cytosol]

Lmna [nuclear envelope]

Inferred From

Lamin A [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001104572.1, XP_006501136.1, NP_062263.1, NP_001002011.2

ENSEMBL

ENSMUSP00000029699, ENSMUST00000120377, ENSMUST00000036252, ENSMUSP00000113093, ENSMUSP00000040265, ENSMUST00000029699, ENSMUSG00000028063

PRO

P48678

GlyGen

P48678

MGI

96794

PDB

1UFG

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31750 Akt1	12	phospho-p-T308,S473-AKT1 [nucleoplasm] (R-MMU-198357) phospho-p-T308,S473-AKT1 [cytosol] (R-MMU-198356) phospho-p-S473-AKT1 [plasma membrane] (R-MMU-377265) AKT1 [plasma membrane] (R-MMU-199416) AKT1 [cytosol] (R-MMU-58252) phospho-p-T308-AKT1 [cytosol] (R-MMU-198634) phospho-p-Y315,Y326-AKT1 [cytosol] (R-MMU-8848757) p-T308,S473-Akt1 [cytosol] (R-MMU-162346) phospho-p-T308,S473-AKT1 [plasma membrane] (R-MMU-199430) Akt1 [cytosol] (R-MMU-189709) phospho-p-S473-AKT1 [cytosol] (R-MMU-9841264) p-T308,S473-Akt1 [plasma membrane] (R-MMU-1445123)	0.564	2
UniProt:Q5FW52 MLIP			0.488	2