Phosphorylated JAK2 phosphorylates the Leptin receptor (LEPR or OB-Rl, long isoform) at multiple tyrosine residues in the C-terminal, cytoplasmic domain (Bjorbaek et al. 1997, White et al. 1997, Ghilardi and Skoda 1997, Carpenter et al. 1998). The phosphotyrosines residues of LEPR then act as docking sites for downstream effectors STAT5, STAT3, SHP2, SH2B1, and SOCS3.
White, DW, Kuropatwinski, KK, Baumann, H, Devos, R, Tartaglia, LA
da Silva, B, Uotani, S, Flier, JS, Bjørbaek, C
Ghilardi, N, Skoda, RC
Symes, A, Stahl, N, Farruggella, TJ, Yancopoulos, GD, Carpenter, LR, Karow, ML
protein tyrosine kinase activity of LEP:LEPR:p-JAK2 [plasma membrane]
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