JAK2 Phosphorylates LEPR

Stable Identifier
Reaction [transition]
Homo sapiens
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Phosphorylated JAK2 phosphorylates the Leptin receptor (LEPR or OB-Rl, long isoform) at multiple tyrosine residues in the C-terminal, cytoplasmic domain (Bjorbaek et al. 1997, White et al. 1997, Ghilardi and Skoda 1997, Carpenter et al. 1998). The phosphotyrosines residues of LEPR then act as docking sites for downstream effectors STAT5, STAT3, SHP2, SH2B1, and SOCS3.

Literature References
PubMed ID Title Journal Year
9020115 Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization

White, DW, Kuropatwinski, KK, Baumann, H, Devos, R, Tartaglia, LA

J. Biol. Chem. 1997
9405487 Divergent signaling capacities of the long and short isoforms of the leptin receptor

da Silva, B, Uotani, S, Flier, JS, Bjørbaek, C

J. Biol. Chem. 1997
9092791 The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line

Ghilardi, N, Skoda, RC

Mol. Endocrinol. 1997
9600917 Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

Symes, A, Stahl, N, Farruggella, TJ, Yancopoulos, GD, Carpenter, LR, Karow, ML

Proc. Natl. Acad. Sci. U.S.A. 1998
Catalyst Activity

protein tyrosine kinase activity of LEP:LEPR:p-JAK2 [plasma membrane]

Inferred From
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