JAK2 Phosphorylates LEPR

Stable Identifier
R-HSA-2586553
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylated JAK2 phosphorylates the Leptin receptor (LEPR or OB-Rl, long isoform) at multiple tyrosine residues in the C-terminal, cytoplasmic domain (Bjorbaek et al. 1997, White et al. 1997, Ghilardi and Skoda 1997, Carpenter et al. 1998). The phosphotyrosines residues of LEPR then act as docking sites for downstream effectors STAT5, STAT3, SHP2, SH2B1, and SOCS3.

Literature References
PubMed ID Title Journal Year
9405487 Divergent signaling capacities of the long and short isoforms of the leptin receptor

Bjørbaek, C, Uotani, S, da Silva, B, Flier, JS

J. Biol. Chem. 1997
9020115 Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization

White, DW, Kuropatwinski, KK, Devos, R, Baumann, H, Tartaglia, LA

J. Biol. Chem. 1997
9092791 The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line

Ghilardi, N, Skoda, RC

Mol. Endocrinol. 1997
9600917 Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

Carpenter, LR, Farruggella, TJ, Symes, A, Karow, ML, Yancopoulos, GD, Stahl, N

Proc. Natl. Acad. Sci. U.S.A. 1998
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of LEP:LEPR:p-JAK2 [plasma membrane]

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