Nid1 degradation by Mmp3, 7

Stable Identifier
R-MMU-2533958
Type
Reaction [transition]
Species
Mus musculus
Compartment
extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Nid1 degradation by Mmp3, 7
Nidogen-1 (entactin) is a member of the nidogen family of basement membrane glycoproteins. It interacts with several other components of basement membranes, notably it connects the collagen and laminin networks to each other (Yurchenko & Patton 2009). MMPs 3, 7 (Mayer et al. 1993), 1, 9, (Sires et al. 1993), 12 (Gronski et al. 1997), 14, 15 (d'Ortho et al. 1997), 19 (Stracke et al. 2000) and leukocyte elastase (Mayer et al. 1993) can all degrade Nidogen-1.
Literature References
PubMed ID Title Journal Year
8223643 Sites of nidogen cleavage by proteases involved in tissue homeostasis and remodelling

Mayer, U, Mann, K, Timpl, R, Murphy, G

Eur J Biochem 1993
Participants
Input
Output
Catalyst Activity

metalloendopeptidase activity of Mmp3, Mmp7 [extracellular region]

Physical Entity
Mmp3, Mmp7 [extracellular region] (Mus musculus)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
NID1 degradation by MMP3, 7 (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-22)
Cite Us!