Activin AB/B binds Activin Receptor Acvr2a:Acvr1c

Stable Identifier
R-MMU-2470495
Type
Reaction [binding]
Species
Mus musculus
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activin AB/B binds Activin Receptor Acvr2a:Acvr1c
Activin B or Activin AB, but not Activin A binds Activin receptors containing the type I receptor Acvr1c (Alk7) with the type II receptor Acvr2a (Tsuchida et al. 2004, Bernard et al. 2006). Binding to receptors containing Acvr2b is inferred.
Literature References
PubMed ID Title Journal Year
15196700 Activin isoforms signal through type I receptor serine/threonine kinase ALK7

Tsuchida, K, Nakatani, M, Yamakawa, N, Hashimoto, O, Hasegawa, Y, Sugino, H

Mol. Cell. Endocrinol. 2004
17040568 Activin B can signal through both ALK4 and ALK7 in gonadotrope cells

Bernard, DJ, Lee, KB, Santos, MM

Reprod. Biol. Endocrinol. 2006
Participants
Input
Output
Orthologous Events
Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C (Homo sapiens)
Authored
May, B  (2012-09-13)
Reviewed
Chen, YG  (2012-11-14)
Created
May, B  (2012-09-19)
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