Activin AB/B binds Activin Receptor ACVR2A/B:ACVR1C

Stable Identifier
R-HSA-2470483
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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Activin AB/B binds Activin Receptor ACVR2A/B:ACVR1C
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As inferred from mouse, Activin binds the Activin receptor composed of a type II receptor (ACVR2A/B) and a type I receptor, in this case ACVR1C (ALK7). It is unclear if the type II receptor and the type I receptor are associated before binding Activin, Activin AB (INHBA:INHBB) and Activin B (INHBB:INHBB), but not Activin A (INHBA:INHBA) can bind and signal via an activin receptor containing the ACVR1C (ALK7) type I receptor.

Participants
Input
Output
Participant Of
hasEvent
Inferred From
Activin AB/B binds Activin Receptor Acvr2a:Acvr1c (Mus musculus)
Authored
May, B  (2012-09-13)
Reviewed
Chen, YG  (2012-11-14)
Created
May, B  (2012-09-19)