Activin AB/B binds Activin Receptor ACVR2A/B:ACVR1C

Stable Identifier
R-HSA-2470483
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activin AB/B binds Activin Receptor ACVR2A/B:ACVR1C
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

As inferred from mouse, Activin binds the Activin receptor composed of a type II receptor (ACVR2A/B) and a type I receptor, in this case ACVR1C (ALK7). It is unclear if the type II receptor and the type I receptor are associated before binding Activin, Activin AB (INHBA:INHBB) and Activin B (INHBB:INHBB), but not Activin A (INHBA:INHBA) can bind and signal via an activin receptor containing the ACVR1C (ALK7) type I receptor.

Participants
Input
Output
Participant Of
hasEvent
Inferred From
Activin AB/B binds Activin Receptor Acvr2a:Acvr1c (Mus musculus)
Authored
May, B  (2012-09-13)
Reviewed
Chen, YG  (2012-11-14)
Created
May, B  (2012-09-19)
Cite Us!