Acvr2a phosphorylates Acvr1c in response to Activin

Stable Identifier
R-MMU-2470487
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Acvr2a phosphorylates Acvr1c in response to Activin
Binding of Activin AB or Activin B to the type II receptor Acvr2a (ActRIIa) causes Acvr2a to phosphorylate the type I receptor Acvr1c (Alk7) (Tsuchida et al. 2004, Bernard et al. 2006).
Literature References
PubMed ID Title Journal Year
15196700 Activin isoforms signal through type I receptor serine/threonine kinase ALK7

Tsuchida, K, Nakatani, M, Yamakawa, N, Hashimoto, O, Hasegawa, Y, Sugino, H

Mol. Cell. Endocrinol. 2004
17040568 Activin B can signal through both ALK4 and ALK7 in gonadotrope cells

Bernard, DJ, Lee, KB, Santos, MM

Reprod. Biol. Endocrinol. 2006
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Activin AB,B:Acvr2a:Acvr1c [plasma membrane]

Physical Entity
Activin AB,B:Acvr2a:Acvr1c [plasma membrane] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin (Homo sapiens)
Authored
May, B  (2012-09-13)
Reviewed
Chen, YG  (2012-11-14)
Created
May, B  (2012-09-19)
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