Phosphorylation of DAP12

Stable Identifier
R-MMU-2395436
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of DAP12
Crosslinking of receptors associated with DAP12 leads to phosphorylation of tyrosine residues in their cytoplasmic ITAM by SRC family kinases (Turnbull & Colonna 2007). This initiates downstream signaling. FYN and LCK have both been found physically and functionally associated with receptors using DAP12 signaling and have been demonstrated to be involved in DAP12 phosphorylation (Mason et al. 2006).
Literature References
PubMed ID Title Journal Year
16709819 Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45

Mason, LH, Willette-Brown, J, Taylor, LS, McVicar, DW

J. Immunol. 2006
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Lck/Fyn [cytosol]

Physical Entity
Lck/Fyn [cytosol] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of DAP12 (Homo sapiens)
Authored
Garapati, P V  (2012-05-25)
Reviewed
Lanier, LL  (2012-08-09)
Created
Garapati, P V  (2012-06-29)
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