Phosphorylation of DAP12

Stable Identifier
R-MMU-2395436
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Phosphorylation of DAP12

Crosslinking of receptors associated with DAP12 leads to phosphorylation of tyrosine residues in their cytoplasmic ITAM by SRC family kinases (Turnbull & Colonna 2007). This initiates downstream signaling. FYN and LCK have both been found physically and functionally associated with receptors using DAP12 signaling and have been demonstrated to be involved in DAP12 phosphorylation (Mason et al. 2006).

Literature References
PubMed ID Title Journal Year
16709819 Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45

Mason, LH, Willette-Brown, J, Taylor, LS, McVicar, DW

J. Immunol. 2006
Participants
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Lck/Fyn [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created