Notch1 gene transcription

Stable Identifier
R-MMU-2247925
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Notch1 gene transcription
Rbpj knockout mouse embryos show severely reduced Notch1 transcription. In addition, transcription of zebrafish Notch1 homologue is severely reduced in zebrafish Mib (mindbomb) mutants (Del Monte et al. 2007). These findings indicate a postive feedback loop in Notch1 gene expression. However, Rbpj binding sites have not been found in mouse or human Notch1 promoter.

In mouse retina, Ccnd1 (cyclin D1) forms a complex with Crebbp and binds Notch1 promoter, stimulating Notch1 transcription. Positive effect of Ccnd1 on Notch1 transcription is also observed in R28 rat retinal precursor cells (Bienvenu et al. 2010).
Literature References
PubMed ID Title Journal Year
17685488 Monitoring Notch1 activity in development: evidence for a feedback regulatory loop

Del Monte, G, Grego-Bessa, J, González-Rajal, A, Bolós, V, De La Pompa, JL

Dev. Dyn. 2007
20090754 Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen

Bienvenu, F, Jirawatnotai, S, Elias, JE, Meyer, CA, Mizeracka, K, Marson, A, Frampton, GM, Cole, MF, Odom, DT, Odajima, J, Geng, Y, Zagozdzon, A, Jecrois, M, Young, RA, Liu, XS, Cepko, CL, Gygi, SP, Sicinski, P

Nature 2010
Participants
Input
Output
This event is regulated
Positively by
Regulator
Notch1 Coactivator Complex [nucleoplasm] (Mus musculus)
Regulator
Ccnd1:Crebbp:Notch1 Gene [nucleoplasm] (Mus musculus)
Orthologous Events
NOTCH1 gene transcription (Homo sapiens)
Authored
Egan, SE  (2012-05-14)
Orlic-Milacic, M  (2012-05-14)
Reviewed
Haw, R  (2012-05-25)
Created
Orlic-Milacic, M  (2012-05-14)
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