Notch2 stimulates transcription of Hes5

Stable Identifier
R-MMU-2197579
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Notch2 stimulates transcription of Hes5
In Chinese hamster ovary (CHO) cells, recombinant mouse Notch2 intracellular domain (NICD2) in complex with recombinant mouse Rbpj (and probably other components of the Notch2 coactivator complex derived from CHO cells, not shown here) stimulates transcription from the mouse Hes5 promoter fused with a reporter luciferase gene (Shimizu et al. 2002).
Literature References
PubMed ID Title Journal Year
11866432 Functional diversity among Notch1, Notch2, and Notch3 receptors

Shimizu, K, Chiba, S, Saito, T, Kumano, K, Hamada, Y, Hirai, H

Biochem Biophys Res Commun 2002
Participants
Input
Output
This event is regulated
Positively by
Regulator
mNICD2:mRbpj:Hes5 gene [nucleoplasm] (Mus musculus)
Regulator
mNICD2:mRbpj:Hes5 gene [nucleoplasm] (Mus musculus)
Active Unit
mNICD2:mRbpj [nucleoplasm]
Orthologous Events
NOTCH2 stimulates transcription of HES5 (Homo sapiens)
Authored
Orlic-Milacic, M  (2013-01-11)
Reviewed
Boyle, S  (2013-04-25)
Ilagan, MXG  (2013-04-25)
Created
Orlic-Milacic, M  (2012-04-12)
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