Notch1 binds Dlk1

Stable Identifier
R-MMU-2071906
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Notch1 binds Dlk1
Using a yeast two-hybrid system, mouse Notch1 and Dlk1 were found to interact and this interaction involves EGF repeats of both proteins. Co-expression of Notch1 and Dlk1 in cis results in inhibition of Notch1-mediated transcription. Notch1 and Dlk1 levels increase at confluence in mouse fibroblast cell culture, which is accompanied by a decreased transcription of the Notch1 target Hes1. Therefore, Dlk1 is implicated as a negative regulator of Notch1 signaling in cis.
Literature References
PubMed ID Title Journal Year
15652348 dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats

Ruiz-Hidalgo, MJ, García-Ramírez, JJ, Nueda, ML, Baladrón, V, Gubina, E, Díaz-Guerra, MJM, Laborda, J, Bonvini, E

Exp Cell Res 2005
Participants
Input
Output
Orthologous Events
NOTCH1 binds DLK1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2012-01-27)
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