NRIF and TRAF6 may activate JNK

Stable Identifier
R-MMU-205060
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
NRIF and TRAF6 may activate JNK

NRIF and TRAF6 appear to cooperate in JNK activation. TRAF6 is involved both in JNK activation and in NF-kB activation. Although the NRIF:TRAF6 interaction enhances by threefold the TRAF6-mediated activation of JNK, it only modestly affects TRAF6-mediated activation of NF-kB.

Literature References
PubMed ID Title Journal Year
15548667 Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice

Yeiser, EC, Rutkoski, NJ, Naito, A, Inoue, J, Carter, BD

J Neurosci 2004
Participants
Catalyst Activity
Catalyst Activity
Title
JUN kinase activity of beta-NGF homodimer:p75NTR:NRIF:TRAF6 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created