NRIF and TRAF6 may activate JNK

Stable Identifier
R-MMU-205060
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NRIF and TRAF6 may activate JNK
NRIF and TRAF6 appear to cooperate in JNK activation. TRAF6 is involved both in JNK activation and in NF-kB activation. Although the NRIF:TRAF6 interaction enhances by threefold the TRAF6-mediated activation of JNK, it only modestly affects TRAF6-mediated activation of NF-kB.
Literature References
PubMed ID Title Journal Year
15548667 Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice

Yeiser, EC, Rutkoski, NJ, Naito, A, Inoue, J, Carter, BD

J Neurosci 2004
Participants
Input
Output
Catalyst Activity

JUN kinase activity of beta-NGF homodimer:p75NTR:NRIF:TRAF6 [plasma membrane]

Physical Entity
beta-NGF homodimer:p75NTR:NRIF:TRAF6 [plasma membrane] (Mus musculus)
Activity
JUN kinase activity (GO:0004705)
Orthologous Events
NRIF and TRAF6 may activate JNK (Homo sapiens)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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