Reactome | FEM1B [cytosol]

FEM1B [cytosol]

Stable Identifier

R-MMU-201572

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q9Z2G0

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        FEM1B [cytosol] (Mus musculus)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        FEM1B [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        FEM1B [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        FEM1B [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        FEM1B [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        FEM1B [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        FEM1B [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        FEM1B [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Mus musculus)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        FEM1B [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        FEM1B [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9Z2G0

Reference Genes

BioGPS Gene:14155

ENSEMBL:ENSMUSG00000032244

KEGG:mmu:14155

Monarch:14155

NCBI Gene:14155

UCSC:Q9Z2G0

Reference Transcript

RefSeq:NM_010193.4

Other Identifiers

10594315

109391_at

14155

1418323_at

1418324_at

160656_i_at

166531_at

17528014

4329341

4794120

4931398

5069603

5449562

5483374

5493011

A_52_P623751

GE35395

GO:0002070

GO:0005123

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006915

GO:0012501

GO:0016567

GO:0022414

GO:0030163

GO:0031462

GO:0043161

GO:0043226

GO:0060090

GO:0060442

GO:0060743

GO:0140627

GO:1902041

GO:1990756

GO:2000001

ILMN_1230162

mMC015793

Participates

as a member of

CUL2-box protein [cytosol] (Mus musculus)

Inferred From

FEM1B [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSMUST00000034775, ENSMUSP00000034775, ENSMUSG00000032244

PRO

Q9Z2G0

MGI

1335087

PDB

7ROY