Reactome | Cd3d [plasma membrane]

Cd3d [plasma membrane]

Stable Identifier

R-MMU-198171

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

CD3D, P04235

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Mus musculus)
    - TCR binds microbial lipid-based antigen via CD1 (Mus musculus)
      - CD1:B2M:microbial lipid:TCR [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
      - T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
    - TCR binds self-lipid-based antigen via CD1 (Mus musculus)
      - CD1:B2M:self-lipid:TCR [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
      - T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
    - TCR complex interacts with peptide antigen-presenting MHC Class I (Mus musculus)
      - T-cell receptor complex with CD8 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
      - TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Mus musculus)
        
        T-cell receptor complex with CD8 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
  - TCR signaling (Mus musculus)
    - Downstream TCR signaling (Mus musculus)
      - Change of PKC theta conformation (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
    - Phosphorylation of CD3 and TCR zeta chains (Mus musculus)
      - Activation of Lck (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
      - Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
      - Inactivation of LCK by PTPN22 (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
      - Inactivation of Lck by Csk (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
      - Phosphorylation of ITAM motifs in CD3 complexes (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
    - Translocation of ZAP-70 to Immunological synapse (Mus musculus)
      - Phosphorylation of ZAP-70 by Lck (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        T-cell receptor complex [plasma membrane] (Mus musculus)
        
        CD3 epsilon delta [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - AP-2 directly binds some endocytic cargo (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        Cd3d [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P04235

Gene Names

Cd3d

Reference Genes

BioGPS Gene:12500 Cd3d

ENSEMBL:ENSMUSG00000032094

ENSEMBL:ENSMUSG00000032094.9 Cd3d

KEGG Gene (Mus musculus):12500 Cd3d

Monarch:12500 Cd3d

NCBI Gene:12500 Cd3d

UCSC:P04235 Cd3d

Reference Transcript

RefSeq:NM_013487.3 Cd3d

Other Identifiers

10584821

12500

1422828_at

17516691

4306846

4404815

4419644

4492484

4562309

4644653

4727657

4857150

5292104

92683_at

A_51_P285206

A_66_P109615

GE36570

GO:0002250

GO:0002376

GO:0004888

GO:0005515

GO:0005886

GO:0007166

GO:0009897

GO:0016020

GO:0023052

GO:0030154

GO:0042101

GO:0042105

GO:0042110

GO:0042802

GO:0045059

GO:0048856

GO:0060089

GO:0065003

ILMN_2697415

ILMN_2697420

mMC008893

x02339_s_at

Participates

as a member of

AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)

as a component of

CD3 epsilon delta [plasma membrane] (Mus musculus)

Other forms of this molecule

Cd3d [clathrin-coated endocytic vesicle membrane]

phospho-Cd3d [plasma membrane]

Inferred From

CD3D [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_038515.3

Ensembl

ENSMUST00000034602, ENSMUSP00000034602, ENSMUSG00000032094

PRO

P04235

MGI

88331

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