Reactome | Klrk1 [plasma membrane]

Klrk1 [plasma membrane]

Stable Identifier

R-MMU-198073

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

KLRK1, O54709

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Mus musculus)
    - NKG2D homodimer interacting with ligands (Mus musculus)
      - Ligand interacting with NKG2D [plasma membrane] (Mus musculus)
        
        NKG2D complexed with DAP10 [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)
      - NKG2D complexed with DAP10 [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)
- Innate Immune System (Mus musculus)
  - DAP12 interactions (Mus musculus)
    - DAP12 signaling (Mus musculus)
      - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Mus musculus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Mus musculus)
        
        DAP12 receptors [plasma membrane] (Mus musculus)
        
        NKG2D dimer [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Mus musculus)
        
        DAP12 receptors [plasma membrane] (Mus musculus)
        
        NKG2D dimer [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)
      - Phosphorylation of BTK by p-SYK (Mus musculus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Mus musculus)
        
        DAP12 receptors [plasma membrane] (Mus musculus)
        
        NKG2D dimer [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)
      - Phosphorylation of LAT by p-SYK (Mus musculus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Mus musculus)
        
        DAP12 receptors [plasma membrane] (Mus musculus)
        
        NKG2D dimer [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Mus musculus)
        
        p-SYK/p-BTK [plasma membrane] (Mus musculus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Mus musculus)
        
        DAP12 receptors [plasma membrane] (Mus musculus)
        
        NKG2D dimer [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)
      - Phosphorylation of SLP-76 by p-SYK (Mus musculus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Mus musculus)
        
        DAP12 receptors [plasma membrane] (Mus musculus)
        
        NKG2D dimer [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)
      - Phosphorylation of SYK (Mus musculus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Mus musculus)
        
        DAP12 receptors [plasma membrane] (Mus musculus)
        
        NKG2D dimer [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)
        
        DAP12 receptors:p-DAP12:SYK [plasma membrane] (Mus musculus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Mus musculus)
        
        DAP12 receptors [plasma membrane] (Mus musculus)
        
        NKG2D dimer [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)
      - Recruitment of SYK to p-DAP12 (Mus musculus)
        
        DAP12 receptors:p-DAP12:SYK [plasma membrane] (Mus musculus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Mus musculus)
        
        DAP12 receptors [plasma membrane] (Mus musculus)
        
        NKG2D dimer [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Mus musculus)
        
        DAP12 receptors [plasma membrane] (Mus musculus)
        
        NKG2D dimer [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)
      - p85 regulatory unit of PI3K binds p-6Y-SYK (Mus musculus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Mus musculus)
        
        DAP12 receptors [plasma membrane] (Mus musculus)
        
        NKG2D dimer [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Mus musculus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Mus musculus)
        
        DAP12 receptors [plasma membrane] (Mus musculus)
        
        NKG2D dimer [plasma membrane] (Mus musculus)
        
        Klrk1 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:O54709 Klrk1

Gene Names

Klrk1, Nkg2d

Chain

chain:1-232

Reference Genes

BioGPS Gene:27007 Klrk1

KEGG:mmu:27007 Klrk1

Monarch:27007 Klrk1

NCBI Gene:27007 Klrk1

UCSC:O54709 Klrk1

Reference Transcript

Other Identifiers

10548345

116484_at

1450495_a_at

17471565

27007

4371868

4393391

4404795

4474259

4489102

4493832

4495352

4502544

4558755

4606931

4608198

4620957

4637477

4733596

4808670

4951818

4979694

5050151

5069867

5094779

5107268

5213679

5233192

5278031

5328158

5329629

5430382

5547467

5571393

93678_s_at

93679_at

A_52_P272778

A_66_P120419

GE41800

GO:0002223

GO:0002250

GO:0002376

GO:0005515

GO:0005886

GO:0006809

GO:0007165

GO:0009897

GO:0009986

GO:0016020

GO:0019900

GO:0030101

GO:0030154

GO:0030246

GO:0032394

GO:0032729

GO:0038023

GO:0042267

GO:0042288

GO:0042802

GO:0045087

GO:0045429

GO:0045954

GO:0050830

GO:0051240

GO:0071222

GO:0098542

GO:2000502

ILMN_1226816

ILMN_1236317

ILMN_2692703

ILMN_2745064

ILMN_2888493

mMC018090

mMC021420

mMR030123

Participates

as a component of

Other forms of this molecule

Nkg2d [plasma membrane]

Inferred From

KLRK1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001076791.1, NP_149069.1

ENSEMBL

ENSMUSG00000030149, ENSMUST00000032252, ENSMUSP00000032252, ENSMUSP00000093061, ENSMUST00000095412

PRO

O54709

GlyGen

O54709

MGI

1196250

PDB

1HQ8, 4PP8

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