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KLRK1 [plasma membrane]
Stable Identifier
R-HSA-198073
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
NKG2D, NKG2-D type II integral membrane protein, NKGD_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
NKG2D homodimer interacting with ligands (Homo sapiens)
Ligand interacting with NKG2D [plasma membrane] (Homo sapiens)
NKG2D complexed with DAP10 [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
NKG2D complexed with DAP10 [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
Phosphorylation of BTK by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
Phosphorylation of DAP12 (Homo sapiens)
DAP12 receptors:DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
Phosphorylation of LAT by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
Phosphorylation of SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
Recruitment of SYK to p-DAP12 (Homo sapiens)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
Interaction of DAP12 and NKG2D (Homo sapiens)
DAP12:NKG2D [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
KLRK1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P26718 KLRK1
Gene Names
KLRK1, D12S2489E, NKG2D
Chain
chain:1-216
Reference Genes
BioGPS Gene:100528032 KLRK1
BioGPS Gene:22914 KLRK1
COSMIC (genes):KLRK1 KLRK1
CTD Gene:100528032 KLRK1
CTD Gene:22914 KLRK1
dbSNP Gene:100528032 KLRK1
dbSNP Gene:22914 KLRK1
ENSEMBL:ENSG00000213809 KLRK1
HGNC:18788 KLRK1
KEGG:hsa:100528032 KLRK1
KEGG:hsa:22914 KLRK1
Monarch:100528032 KLRK1
Monarch:22914 KLRK1
NCBI Gene:100528032 KLRK1
NCBI Gene:22914 KLRK1
OMIM:611817 KLRK1
UCSC:P26718 KLRK1
Reference Transcript
RefSeq:NM_001199805.1 KLRK1
RefSeq:NM_007360.3 KLRK1
Other Identifiers
100528032
11727694_a_at
11727695_a_at
1555691_PM_a_at
1555691_a_at
16761326
205821_PM_at
205821_at
22914
3444087
3444088
3444089
3444090
3444091
3444092
3444093
3444094
3444095
3444096
3444097
3444098
3444099
3444100
3444101
3444102
36777_at
7961151
A_24_P193093
GE81744
GO:0002223
GO:0002250
GO:0002376
GO:0005515
GO:0005886
GO:0006809
GO:0007165
GO:0009897
GO:0009986
GO:0016020
GO:0030101
GO:0030154
GO:0030246
GO:0031295
GO:0032394
GO:0032729
GO:0034260
GO:0038023
GO:0042267
GO:0042288
GO:0042802
GO:0045087
GO:0045429
GO:0045954
GO:0050830
GO:0060089
GO:0071222
GO:0098542
GO:2000502
HMNXSV003054588
Hs2.74085.2.S1_3p_s_at
ILMN_2222443
PH_hs_0033086
X54870_at
g6679051_3p_at
Participates
as a component of
NKG2D complexed with DAP10 [plasma membrane] (Homo sapiens)
NKG2D dimer [plasma membrane] (Homo sapiens)
Inferred To
KLRK1 [plasma membrane]
(Bos taurus)
KLRK1 [plasma membrane]
(Canis familiaris)
KLRK1 [plasma membrane]
(Sus scrofa)
Klrk1 [plasma membrane]
(Mus musculus)
Klrk1 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_031386.2
,
NP_001186734.1
ENSEMBL
ENSP00000240618
,
ENSP00000446003
,
ENST00000240618
,
ENST00000540818
OpenTargets
ENSG00000213809
HPA
ENSG00000213809-KLRK1
PRO
P26718
Pharos - Targets
P26718
GlyGen
P26718
PDB
1KCG
,
1MPU
,
1HYR
,
8TM0
,
8TM2
,
4PDC
,
4S0U
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