Reactome | PDX1 transactivates Iapp

PDX1 transactivates Iapp

Stable Identifier

R-MMU-186609

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Binding of Pdx1 to the 5'-flanking region of the IAPP gene was observed in vitro (Carty et al. 1997) and in transient transfection studies with rat cell lines (Serup et al. 1996). Reduced activity of IAPP was reported in mature murine beta cells with targeted disruption of Pdx1 (Ahlgren et al. 1998). This is consistent with the expression profile from the dominant negative suppression of Pdx1 in rat insulinoma INS1 cell line-derived stable clones (Wang et al. 2001). ChIP experiments confirmed that Pdx1 binds in vivo to the IAPP gene in murine beta cell lines (Chakrabarti et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
9637677	beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes Ahlgren, U, Jonsson, J, Jonsson, L, Simu, K, Edlund, H	Genes Dev	1998
11825903	Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. Chakrabarti, SK, James, JC, Mirmira, RG	J Biol Chem	2002

Participants

Output

iapp [cytosol] (Mus musculus)

This event is regulated

Positively by

Regulator

ipf1/pdx1 [nucleoplasm] (Mus musculus)

Orthologous Events

PDX1-dependent synthesis of IAPP protein (Homo sapiens)

Authored

Ferrer, J (2008-05-24)

Tello-Ruiz, MK (2008-05-24)

Reviewed

Jensen, J (2008-05-13)

Created

Tello-Ruiz, MK (2006-08-14)

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