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PDX1-dependent synthesis of IAPP protein
Stable Identifier
R-HSA-211301
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Regulation of beta-cell development (Homo sapiens)
Regulation of gene expression in beta cells (Homo sapiens)
PDX1-dependent synthesis of IAPP protein (Homo sapiens)
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The IAPP gene, encoding islet amyloid precursor protein, is transcribed and its mRNA is translated. IAPP transcription is positively regulated by PDX1 transcription factor. These events and interactions are inferred from corresponding ones studied in molecular detail in the mouse.
Participants
Input
IAPP gene [nucleoplasm]
(Homo sapiens)
Output
IAPP(1-89) [cytosol]
(Homo sapiens)
Participates
as an event of
Regulation of gene expression in beta cells (Homo sapiens)
This event is regulated
Positively by
Regulator
PDX1 [nucleoplasm]
(Homo sapiens)
Inferred From
PDX1 transactivates Iapp (Mus musculus)
Authored
Tello-Ruiz, MK (2008-05-24)
Ferrer, J (2008-05-24)
Reviewed
Jensen, J (2008-05-13)
Created
D'Eustachio, P (2008-01-31)
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