PDX1 transactivates Nkx6.1

Stable Identifier
R-MMU-186524
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PDX1 transactivates Nkx6.1
Binding of Pdx1 to the 5'-flanking region of the mouse Nkx6.1 gene was observed in vitro and in transient transfection studies with pancreatic islet cell lines (Watada et al. 2000). Reduced activity of Nkx6.1 was reported in mature murine beta cells with targeted disruption of Pdx1 (Ahlgren et al. 1998). This is consistent with the expression profile from the dominant negative suppression of Pdx1 in rat insulinoma INS1 cell line-derived stable clones (Wang et al. 2001).
Literature References
PubMed ID Title Journal Year
16297379 Endodermal expression of Nkx6 genes depends differentially on Pdx1

Pedersen, JK, Nelson, SB, Jorgensen, MC, Henseleit, KD, Fujitani, Y, Wright, CV, Sander, M, Serup, P

Dev Biol 2005
10938085 Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1.

Watada, H, Mirmira, RG, Leung, J, German, MS

J Biol Chem 2000
17537793 The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells

Nelson, SB, Schaffer, AE, Sander, M

Development 2007
9637677 beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

Ahlgren, U, Jonsson, J, Jonsson, L, Simu, K, Edlund, H

Genes Dev 1998
Participants
Output
This event is regulated
Positively by
Regulator
ipf1/pdx1 [nucleoplasm] (Mus musculus)
Orthologous Events
PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)
Authored
Ferrer, J  (2008-05-24)
Tello-Ruiz, MK  (2008-05-24)
Reviewed
Jensen, J  (2008-05-13)
Created
Tello-Ruiz, MK  (2006-08-14)
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