PDX1-dependent synthesis of NKX6-1 protein

Stable Identifier
R-HSA-211350
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PDX1-dependent synthesis of NKX6-1 protein
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In mature beta-cells of the pancreas, the NKX6-1 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. NKX6-1 transcription is positively regulated by the activity of the PDX1 transcription factor. These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse.
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
PDX1 [nucleoplasm] (Homo sapiens)
Inferred From
PDX1 transactivates Nkx6.1 (Mus musculus)
Authored
Tello-Ruiz, MK  (2008-05-24)
Ferrer, J  (2008-05-24)
Reviewed
Jensen, J  (2008-05-13)
Created
D'Eustachio, P  (2008-02-02)
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