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EPS15:HGS:STAM [cytosol]
Stable Identifier
R-MMU-182947
Type
Complex
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by EGFR (Mus musculus)
EGFR downregulation (Mus musculus)
CBL-mediated ubiquitination of CIN85 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Mus musculus)
EPS15:HGS:STAM [cytosol] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Mus musculus)
EPS15:HGS:STAM [cytosol] (Mus musculus)
EGFR binds EPS15, EPN1, EPS15L1 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Mus musculus)
EPS15:HGS:STAM [cytosol] (Mus musculus)
EPS15:HGS:STAM [cytosol] (Mus musculus)
EGFR non-clathrin mediated endocytosis (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Mus musculus)
EPS15:HGS:STAM [cytosol] (Mus musculus)
EPS15:HGS:STAM [cytosol] (Mus musculus)
EGFR phosphorylates EPS15 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Mus musculus)
EPS15:HGS:STAM [cytosol] (Mus musculus)
PTPN3 dephosphorylates EPS15 (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Mus musculus)
EPS15:HGS:STAM [cytosol] (Mus musculus)
Sprouty sequesters CBL away from active EGFR (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Mus musculus)
EPS15:HGS:STAM [cytosol] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Mus musculus)
EPS15:HGS:STAM [cytosol] (Mus musculus)
Signaling by MET (Mus musculus)
Negative regulation of MET activity (Mus musculus)
EPS15 and HGS bind ubiquitinated MET (Mus musculus)
EPS15:HGS:STAM [cytosol] (Mus musculus)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Mus musculus)
EPS15:HGS:STAM [cytosol] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
EPS15 [cytosol]
(Mus musculus)
HGS [cytosol]
(Mus musculus)
STAM [cytosol]
(Mus musculus)
Participates
as a component of
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Mus musculus)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Mus musculus)
as an input of
EGFR non-clathrin mediated endocytosis (Mus musculus)
EGFR binds EPS15, EPN1, EPS15L1 (Mus musculus)
EPS15 and HGS bind ubiquitinated MET (Mus musculus)
Inferred From
EPS15:HGS:STAM [cytosol]
(Homo sapiens)
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