Reactome | phospho-Gab1 [cytosol]

phospho-Gab1 [cytosol]

Stable Identifier

R-MMU-180344

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-5Y-GAB1, Q9QYY0

Locations in the PathwayBrowser

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Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - RET signaling (Mus musculus)
      - GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
      - p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - Negative regulation of the PI3K/AKT network (Mus musculus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
        
        PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
        
        Activator:PI3K [plasma membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
    - PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
      - Activator:PI3K [plasma membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by EGFR (Mus musculus)
    - GAB1 signalosome (Mus musculus)
      - Activation of SHP2 through the binding to phospho-Gab1 (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
      - Dephosphorylation of Gab1 by SHP2 (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
      - Dephosphorylation of PAG by SHP2 (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
      - GAB1 phosphorylation by EGFR kinase (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
      - PI3K binds to EGF:EGFR:GRB2:GAB1 (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
      - PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
      - SHP2 dephosphorylates Tyr 992 on EGFR (Mus musculus)
        
        EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
      - Sustained activation of SRC kinase by SHP2 (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Mus musculus)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Mus musculus)
        
        GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
  - Signaling by MET (Mus musculus)
    - MET activates PI3K/AKT signaling (Mus musculus)
      - MET bound PI3K generates PIP3 (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
      - MET phosphorylates GAB1 (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
      - Phosphorylated GAB1 recruits PI3K to MET (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
    - MET activates PTPN11 (Mus musculus)
      - GAB1 binds PTPN11 (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
    - MET promotes cell motility (Mus musculus)
      - MET activates RAP1 and RAC1 (Mus musculus)
        
        CRK,CRKL recruits RAC1 GEF to activated MET (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        DOCK7 activates RAC1 (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        GAB1 recruits CRK,CRKL to MET (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        RAPGEF1 activates RAP1 (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        RAPGEF1 binds CRK,CRKL (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
    - MET receptor recycling (Mus musculus)
      - GGA3 associates with activated MET receptor (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
      - RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Mus musculus)
        
        phospho-Gab1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9QYY0 Gab1

Gene Names

Gab1

Chain

initiator methionine:1, chain:2-695

Reference Genes

BioGPS Gene:14388 Gab1

KEGG:mmu:14388 Gab1

Monarch:14388 Gab1

NCBI Gene:14388 Gab1

UCSC:Q9QYY0 Gab1

Reference Transcript

RefSeq:NM_021356.2 Gab1

Other Identifiers

10579925

1417693_a_at

1417694_at

14388

1445547_at

1448814_at

160714_at

17510823

4309845

4325343

4390182

4431814

4446635

4512199

4516606

4533801

4713422

4776335

4894124

4898760

4949382

4996132

5054038

5126698

5234923

5283040

5290972

5436325

5531559

93902_at

A_52_P417437

GE37913

GO:0000165

GO:0001525

GO:0005515

GO:0005737

GO:0005829

GO:0005911

GO:0005938

GO:0006979

GO:0007165

GO:0007173

GO:0007507

GO:0008544

GO:0030334

GO:0035556

GO:0035591

GO:0035767

GO:0035924

GO:0038084

GO:0043410

GO:0043536

GO:0045766

GO:0048008

GO:0048856

GO:0048870

GO:0060090

GO:0060711

GO:0070102

ILMN_1222009

ILMN_2499294

aa034739_s_at

mMC002435

Participates

as a member of

p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Mus musculus)

as a component of

Other forms of this molecule

phospho-Gab1 [cytosol]

Gab1 [cytosol]

Inferred From

p-5Y-GAB1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 627 (in Homo sapiens)

Coordinate

627

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 659 (in Homo sapiens)

Coordinate

659

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 447 (in Homo sapiens)

Coordinate

447

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 472 (in Homo sapiens)

Coordinate

472

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 589 (in Homo sapiens)

Coordinate

589

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_067331.2

ENSEMBL

ENSMUSP00000034150, ENSMUST00000034150, ENSMUSG00000031714

PRO

Q9QYY0

GlyGen

Q9QYY0

MGI

108088

HMDB Protein

HMDBP13419

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60631 Grb2	3	Grb2 [cytosol] (R-MMU-74686) Grb2 [plasma membrane] (R-MMU-202993) Grb2 [cytosol] (R-MMU-443287)	0.791	9
UniProt:O15357 INPPL1	1	INPPL1 [cytosol] (R-HSA-913354)	0.508	5
UniProt:Q80UI5 Q80UI5			0.508	5

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