Reactome | Psma7 [nucleoplasm]

Psma7 [nucleoplasm]

Stable Identifier

R-MMU-174351

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

PSMA7, Q9Z2U0

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G1/S DNA Damage Checkpoints (Mus musculus)
    - p53-Independent G1/S DNA Damage Checkpoint (Mus musculus)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Mus musculus)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma7 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Cyclin E associated events during G1/S transition (Mus musculus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma7 [nucleoplasm] (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma7 [nucleoplasm] (Mus musculus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Mus musculus)
        
        Degradation of multiubiquitinated Cdh1 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma7 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma7 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to chemical stress (Mus musculus)
    - KEAP1-NFE2L2 pathway (Mus musculus)
      - Nuclear events mediated by NFE2L2 (Mus musculus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Mus musculus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma7 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX2 (Mus musculus)
      - Regulation of RUNX2 expression and activity (Mus musculus)
        
        26S proteasome degrades PolyUb-RUNX2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma7 [nucleoplasm] (Mus musculus)
    - Transcriptional regulation by RUNX3 (Mus musculus)
      - Regulation of RUNX3 expression and activity (Mus musculus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP outer ring [nucleoplasm] (Mus musculus)
        
        Psma7 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9Z2U0 Psma7

Gene Names

Psma7

Chain

chain:1-248

Reference Genes

BioGPS Gene:26444 Psma7

KEGG:mmu:26444 Psma7

Monarch:26444 Psma7

NCBI Gene:26444 Psma7

UCSC:Q9Z2U0 Psma7

Reference Transcript

RefSeq:NM_011969.2 Psma7

Other Identifiers

10490370

1423567_a_at

1423568_at

17395488

26444

4349029

4376829

4436576

4600709

4609796

4622301

4631227

4656483

4684136

4883031

4926027

4941203

4972486

5022211

5059194

5070119

5097103

5205694

5270734

5339766

5449102

5552361

5559503

5585866

93988_at

A_51_P233603

A_52_P615658

GE36431

GO:0000502

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006511

GO:0019773

GO:0030163

GO:0042802

GO:0043161

GO:0051603

ILMN_2630328

ILMN_2793488

aa592029_s_at

mMC009072

Participates

as a component of

20S CP outer ring [nucleoplasm] (Mus musculus)

Other forms of this molecule

Psma7 [nucleoplasm]

Psma7 [cytosol]

Inferred From

PSMA7 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_036099.1

ENSEMBL

ENSMUSP00000029082, ENSMUSG00000027566, ENSMUST00000029082

PRO

Q9Z2U0

GlyGen

Q9Z2U0

MGI

1347070

PDB

3UNH, 8YPK, 3UNF, 3UNB, 8YVP, 3UNE

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