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MAP3K14 [cytosol]
Stable Identifier
R-MMU-168189
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q9WUL6
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Regulation of T cell activation by CD28 family (Mus musculus)
Co-stimulation by CD28 (Mus musculus)
CD28 dependent PI3K/Akt signaling (Mus musculus)
p-S400-Cot phosphorylates NIK (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
TNFR2 non-canonical NF-kB pathway (Mus musculus)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Mus musculus)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Mus musculus)
K48polyUb-TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
NIK-->noncanonical NF-kB signaling (Mus musculus)
Activation of NIK (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Active NIK phosphorylates IKKA dimer (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Mus musculus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
NIK autophosphorylates on T559 (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Mus musculus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Mus musculus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
p100:RELB binds active NIK:p-IKKA dimer (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Protesomal degradation of K48polyUb-TRAF3 (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Mus musculus)
K48polyUb-TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Mus musculus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Mus musculus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Mus musculus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Mus musculus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
TRAF3 binds BAFFR:BAFF (Mus musculus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
TRAFs bind RANK:RANKL (Mus musculus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Mus musculus)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Mus musculus)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
TRAF3:NIK binds TRAF2:cIAP1/2 (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Mus musculus)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Mus musculus)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Mus musculus)
TRAF3:NIK [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
Dectin-1 mediated noncanonical NF-kB signaling (Mus musculus)
Activation of NIK (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Active NIK phosphorylates IKKA dimer (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Mus musculus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Mus musculus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Mus musculus)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
p100:RELB binds active NIK:p-IKKA dimer (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
MAP3K14 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9WUL6
Reference Genes
BioGPS Gene:53859
ENSEMBL:ENSMUSG00000020941
KEGG:mmu:53859
Monarch:53859
NCBI Gene:53859
UCSC:Q9WUL6
Reference Transcript
RefSeq:NM_016896.3
Other Identifiers
10391870
140564_at
1422999_at
1434364_at
17270453
4444189
4476985
4536766
4570365
4580621
4589523
4609264
4615620
4642895
4664378
4671336
4797462
4821791
4833854
4843434
4908226
4939078
5001364
5092488
5160034
5187869
5280795
5291650
5310744
5336053
5347923
53859
5491884
5531021
5542326
5561313
A_52_P364130
A_55_P1988664
GE37135
GO:0000165
GO:0001650
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005654
GO:0005737
GO:0005829
GO:0006468
GO:0006955
GO:0007249
GO:0016301
GO:0016740
GO:0038061
GO:0043226
GO:0043231
GO:0051607
GO:0071260
GO:0098542
GO:0106310
GO:0140096
ILMN_1241869
ILMN_2665050
mMC022213
Participates
as an input of
NIK autophosphorylates on T559 (Mus musculus)
Active NIK phosphorylates IKKA dimer (Mus musculus)
Activation of NIK (Mus musculus)
p-S400-Cot phosphorylates NIK (Mus musculus)
as an output of
Activation of NIK (Mus musculus)
Protesomal degradation of K48polyUb-TRAF3 (Mus musculus)
as a component of
TRAF3:NIK [cytosol] (Mus musculus)
K48polyUb-TRAF3:NIK [cytosol] (Mus musculus)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Mus musculus)
Other forms of this molecule
phospho-p-T559-MAP3K14 [cytosol]
K48polyUb-NIK [cytosol]
phospho-p-MAP3K14 [cytosol]
Inferred From
MAP3K14 [cytosol]
(Homo sapiens)
Active NIK [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_058592.1
ENSEMBL
ENSMUSP00000021324
,
ENSMUST00000021324
IntEnz
2.7.11.25
PRO
Q9WUL6
MGI
1858204
PDB
4G3G
,
5T8O
,
6G4Y
,
6G4Z
,
6MYN
,
5T8P
,
7SZR
,
4G3E
,
4G3F
,
5T8Q
,
4G3C
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