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C3 [extracellular region]
Stable Identifier
R-MMU-166821
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
C3 beta chain, P01027
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Complement cascade (Mus musculus)
Activation of C3 and C5 (Mus musculus)
Activation of C5 (Mus musculus)
C5 convertases [plasma membrane] (Mus musculus)
C3b:Bb:C3b:Properdin [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
C4b:C2a:C3b [plasma membrane] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cleavage of C3 by C3 convertases (Mus musculus)
C3 convertases [plasma membrane] (Mus musculus)
C3(H2O):Bb [extracellular region] (Mus musculus)
C3(H2O) [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
C4b:C2a:C3b [plasma membrane] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b:Bb [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Complement factor 3 [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Formation of classic pathway C5 convertase (Mus musculus)
C4b:C2a:C3b [plasma membrane] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Initial triggering of complement (Mus musculus)
Alternative complement activation (Mus musculus)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Mus musculus)
C3(H2O):Bb [extracellular region] (Mus musculus)
C3(H2O) [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Complement factor 3 [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
C3b binds to cell surface (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Factor B binds to C3(H2O) (Mus musculus)
C3(H2O) [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
C3(H2O):CFB [extracellular region] (Mus musculus)
C3(H2O) [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Factor B binds to surface-associated C3b (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b:CFB [plasma membrane] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Factor D cleaves C3(H2O)-bound Factor B (Mus musculus)
C3(H2O):Bb [extracellular region] (Mus musculus)
C3(H2O) [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
C3(H2O):CFB [extracellular region] (Mus musculus)
C3(H2O) [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Factor D cleaves C3b-bound Factor B (Mus musculus)
Cell surface:C3b:Bb [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b:CFB [plasma membrane] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Formation of alternative pathway C5 convertase (Mus musculus)
C3b:Bb:C3b:Properdin [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Complement factor 3 [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Properdin stabilizes C3b:Bb bound to cell surfaces (Mus musculus)
Cell surface:C3b:Bb [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Spontaneous hydrolysis of C3 thioester (Mus musculus)
C3(H2O) [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Complement factor 3 [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Regulation of Complement cascade (Mus musculus)
C3 convertases spontaneously dissociate (Mus musculus)
C3 convertases [plasma membrane] (Mus musculus)
C3(H2O):Bb [extracellular region] (Mus musculus)
C3(H2O) [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
C4b:C2a:C3b [plasma membrane] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b:Bb [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
C3(H2O) [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
CD46 binds C3b (Mus musculus)
CD46:Cell surface:C3b [plasma membrane] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
CD55 (DAF) binds C3bBb, C4bC2a (Mus musculus)
C4bC2a, C3bBb [plasma membrane] (Mus musculus)
Cell surface:C3b:Bb [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
CD55:C3 convertase complexes [plasma membrane] (Mus musculus)
CD55:C3bBb [plasma membrane] (Mus musculus)
Cell surface:C3b:Bb [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Mus musculus)
CD55:C3 convertase complexes [plasma membrane] (Mus musculus)
CD55:C3bBb [plasma membrane] (Mus musculus)
Cell surface:C3b:Bb [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
CD55:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
CFHR dimers bind C3b (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Cell surface:C3b:CFHR dimers [plasma membrane] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Complement factor I binds to MCP, CR1:C4b, C3b (Mus musculus)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Mus musculus)
CD46:Cell surface:C3b [plasma membrane] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Mus musculus)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Mus musculus)
CD46:Cell surface:C3b [plasma membrane] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
Factor I inactivates MCP/CR1-bound C4b/C3b (Mus musculus)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Mus musculus)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Mus musculus)
CD46:Cell surface:C3b [plasma membrane] (Mus musculus)
Cell surface:C3b [plasma membrane] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3 [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:P01027
Gene Names
C3
Reference Genes
BioGPS Gene:12266 C3
ENSEMBL:ENSMUSG00000024164
KEGG:mmu:12266 C3
Monarch:12266 C3
NCBI Gene:12266 C3
UCSC:P01027 C3
Reference Transcript
RefSeq:NM_009778.3 C3
Other Identifiers
10452316
12266
1423954_at
17346528
4309389
4311249
4348214
4382215
4385002
4396170
4400230
4434499
4441439
4535567
4536499
4545292
4555914
4563180
4596468
4688264
4738818
4781260
4836556
4861427
4863295
4865535
4877213
4878574
4901781
4934181
4948713
5032829
5058604
5061514
5067944
5126394
5149554
5155546
5155756
5190575
5236090
5242194
5284925
5411288
5455035
5501915
5514121
5580395
93497_at
A_51_P110301
A_52_P133594
A_55_P2038525
GE32929
GO:0001798
GO:0001934
GO:0001970
GO:0002376
GO:0002430
GO:0004866
GO:0005515
GO:0005576
GO:0005615
GO:0006629
GO:0006631
GO:0006954
GO:0006956
GO:0006957
GO:0006958
GO:0008289
GO:0009617
GO:0009986
GO:0010575
GO:0010828
GO:0010866
GO:0010884
GO:0016322
GO:0022414
GO:0031715
GO:0032991
GO:0034330
GO:0035846
GO:0042113
GO:0045745
GO:0045766
GO:0048018
GO:0048260
GO:0048639
GO:0048856
GO:0050766
GO:0060100
GO:0070374
GO:0097242
GO:0097278
GO:0098542
GO:0098772
GO:0150062
GO:0150064
GO:2000427
ILMN_1230789
ILMN_2759484
k02782_s_at
mMC002502
Participates
as a component of
Complement factor 3 [extracellular region] (Mus musculus)
C3b [extracellular region] (Mus musculus)
C3(H2O) [extracellular region] (Mus musculus)
Other forms of this molecule
C3 [extracellular region]
C3 [azurophil granule lumen]
C3 [azurophil granule lumen]
C3 [secretory granule lumen]
C3 [secretory granule lumen]
phospho-C3 [endoplasmic reticulum lumen]
C3 [endoplasmic reticulum lumen]
C3 [extracellular region]
C3 [plasma membrane]
C3 [plasma membrane]
C3 [extracellular region]
C3 [plasma membrane]
C3 [plasma membrane]
C3 [plasma membrane]
C3 [extracellular region]
C3 [extracellular region]
C3 [extracellular region]
C3 [extracellular region]
Inferred From
C3 beta chain [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_033908.2
ENSEMBL
ENSMUST00000024988
,
ENSMUSP00000024988
PRO
P01027
GlyGen
P01027
MGI
88227
PDB
6XZU
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