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phospho-Irf3 [cytosol]
Stable Identifier
R-MMU-166258
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
p-4S,T404-IRF3, P70671
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Cytosolic sensors of pathogen-associated DNA (Mus musculus)
STING mediated induction of host immune responses (Mus musculus)
IRF3-mediated induction of type I IFN (Mus musculus)
Dimerized phospho-IRF3 migrates to the nucleus (Mus musculus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
IRF3 is phosphorylated by TBK1 (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
p-T,4S-IRF3 is dimerized (Mus musculus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
ZBP1(DAI) mediated induction of type I IFNs (Mus musculus)
IRF3 mediated activation of type 1 IFN (Mus musculus)
Dimerized phospho-IRF3 migrates to the nucleus (Mus musculus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
p-T,4S-IRF3 is dimerized (Mus musculus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Mus musculus)
TRAF3-dependent IRF activation pathway (Mus musculus)
Dimerization of Phospho IRF3 or phospho IRF7 (Mus musculus)
IRF3-P:IRF7-P [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Mus musculus)
IRF3-P:IRF7-P [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TICAM1-dependent activation of IRF3/IRF7 (Mus musculus)
Dimerization of phosphorylated IRF3/IRF7 (Mus musculus)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Mus musculus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Mus musculus)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Mus musculus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Mus musculus)
Dimerization of phosphorylated IRF3/IRF7 (Mus musculus)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Mus musculus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Mus musculus)
phosphorylated IRF3 and/or IRF7 dimer [cytosol] (Mus musculus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Mus musculus)
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Mus musculus)
phospho-Irf3 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P70671 Irf3
Gene Names
Irf3
Chain
chain:1-419
Reference Genes
BioGPS Gene:54131 Irf3
ENSEMBL:ENSMUSG00000003184.16 Irf3
KEGG Gene (Mus musculus):54131 Irf3
Monarch:54131 Irf3
NCBI Gene:54131 Irf3
UCSC:P70671 Irf3
Reference Transcript
RefSeq:XM_006540996.2 Irf3
RefSeq:NM_016849.4 Irf3
RefSeq:XM_006540995.3 Irf3
Other Identifiers
10552812
1416898_a_at
1426111_x_at
1438721_a_at
17477655
4320179
4470726
4518155
4554517
4596546
4687514
4890949
4985828
5019938
54131
5557860
5573446
5593052
99103_at
A_51_P485499
A_52_P609770
A_55_P2083939
A_55_P2745005
GE37117
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001216
GO:0001227
GO:0001228
GO:0001819
GO:0002376
GO:0002753
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006954
GO:0009299
GO:0009617
GO:0010468
GO:0012501
GO:0016071
GO:0019904
GO:0023052
GO:0031663
GO:0032481
GO:0032496
GO:0032727
GO:0032728
GO:0034142
GO:0035666
GO:0042802
GO:0042803
GO:0042981
GO:0043123
GO:0043226
GO:0043330
GO:0043565
GO:0045087
GO:0045893
GO:0045944
GO:0050727
GO:0051607
GO:0060337
GO:0060340
GO:0071222
GO:0097300
GO:0098542
GO:0098586
GO:0140110
GO:0140374
GO:1990837
GO:1990841
ILMN_1224505
ILMN_1229320
ILMN_2661346
ILMN_2664319
mMC016344
u75839_s_at
Participates
as an input of
p-T,4S-IRF3 is dimerized (Mus musculus)
as an output of
IRF3 is phosphorylated by TBK1 (Mus musculus)
as a member of
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] (Mus musculus)
as a component of
IRF3-P:IRF7-P [cytosol] (Mus musculus)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Mus musculus)
Other forms of this molecule
Irf3 [cytosol]
phospho-Irf3 [nucleoplasm]
phospho-Irf3 [nucleoplasm]
Irf3 [cytosol]
Inferred From
p-4S,T404-IRF3 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 396 (in Homo sapiens)
Coordinate
396
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 398 (in Homo sapiens)
Coordinate
398
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 402 (in Homo sapiens)
Coordinate
402
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 405 (in Homo sapiens)
Coordinate
405
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 404 (in Homo sapiens)
Coordinate
404
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_006541059.1
,
XP_006541058.1
,
NP_058545.1
Ensembl
ENSMUSP00000103465
,
ENSMUSP00000003284
,
ENSMUST00000209066
,
ENSMUST00000003284
,
ENSMUSG00000003184
,
ENSMUSP00000146773
,
ENSMUST00000107834
PRO
P70671
MGI
1859179
PDB
7JFM
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P70671 Irf3
5
Irf3 [cytosol]
(R-MMU-1810466)
phospho-Irf3 [nucleoplasm]
(R-MMU-936418)
phospho-Irf3 [nucleoplasm]
(R-MMU-177654)
phospho-Irf3 [cytosol]
(R-MMU-166258)
Irf3 [cytosol]
(R-MMU-166251)
0.702
3
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